ChemicalBook > CAS DataBase List > TTP 22

TTP 22

Product Name
TTP 22
CAS No.
329907-28-0
Chemical Name
TTP 22
Synonyms
TTP 22;CS-886;TTP 22, >97%;TTP22; TTP-22;TTP 22, >=98%;Casein Kinase,Inhibitor,TTP-22,TTP 22,inhibit,TTP22;3-(5-P-TOLYLTHIENO[2,3-D]PYRIMIDIN-4-YLTHIO)PROPANOIC ACID;3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid;Propanoic acid, 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]-;3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid
CBNumber
CB42596587
Molecular Formula
C16H14N2O2S2
Formula Weight
330.42
MOL File
329907-28-0.mol
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TTP 22 Property

storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥7.85 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
color 
White to gray
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17702
Product name
TTP 22
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17702
Product name
TTP 22
Purity
≥95%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
17702
Product name
TTP 22
Purity
≥95%
Packaging
10mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
17702
Product name
TTP 22
Purity
≥95%
Packaging
50mg
Price
$836
Updated
2024/03/01
Tocris
Product number
4432
Product name
TTP22
Purity
≥98%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
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TTP 22 Chemical Properties,Usage,Production

Uses

TTP 22 is a CK2 inhibitor.

Biological Activity

ttp 22 is a high affinity, atp-competitive casein kinase 2 (ck2) inhibitor.casein kinase 2 (ck2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. these features make ck2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. thus, currently ck2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs.

in vitro

kinetic studies of ttp 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with atp molecule for the binding site. inhibition constant (ki) for ttp 22 was 40 nm. initial in vitro tests of ttp 22 and it analog on four serine/threonine (ask1, jnk3, aurora a and rock 1) and three tyrosine protein kinases (fgfr1, met and tie2) revealed their remarkable specificity towards ck2 [1].

IC 50

= 0.1 μm; ki= 40 nm

storage

Store at +4°C

References

[1] golub ag,bdzhola vg,briukhovetska nv,balanda ao,kukharenko op,kotey im,ostrynska ov,yarmoluk sm. synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase ck2. eur j med chem.2011 mar;46(3):870-6.

TTP 22 Preparation Products And Raw materials

Raw materials

Preparation Products

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TTP 22 Suppliers

China 67 India 1 United Kingdom 1 United States 16 Global 85
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Target molecule Corp.
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857-239-0968
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857-239-8801
Email
service1@targetmol.com
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United States
ProdList
2559
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60
Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
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32063
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
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6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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United States
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57505
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ApexBio Technology
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NE Scientific
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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81
United States Biological
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chemicals@usbio.net
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Creative Enzymes
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MedChemExpress
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Combi-Blocks Inc.
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Axon Medchem LLC
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United States
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
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United States
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3597
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View Lastest Price from TTP 22 manufacturers

Career Henan Chemical Co
Product
TTP 22 329907-28-0
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

329907-28-0, TTP 22Related Search:

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  • TTP 22
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  • 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid
  • 3-(5-P-TOLYLTHIENO[2,3-D]PYRIMIDIN-4-YLTHIO)PROPANOIC ACID
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  • TTP 22, >97%
  • 3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid
  • Casein Kinase,Inhibitor,TTP-22,TTP 22,inhibit,TTP22
  • 329907-28-0
  • Inhibitors