ChemicalBook > CAS DataBase List > 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

Product Name: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
CAS No.: 199864-86-3
Chemical Name: 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
Synonyms: MT 500 Hydrochloride;RS 127445 hydrochloride NEW;RS-127445 hydrochloride, 10 mM in DMSO;4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine;2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride;2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride;4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride;2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
CBNumber: CB42609717
Molecular Formula: C17H17ClFN3
Formula Weight: 317.7883832
MOL File: 199864-86-3.mol

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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Property

Melting point:: 158 °C
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
color: white to tan

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933.59.5300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R2533
Product name: RS-127445 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $133
Updated: 2025/07/31

Sigma-Aldrich

Product number: R2533
Product name: RS-127445 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $514
Updated: 2025/07/31

TCI Chemical

Product number: R0221
Product name: RS-127445 Hydrochloride
Packaging: 10MG
Price: $190
Updated: 2025/07/31

TCI Chemical

Product number: R0221
Product name: RS-127445 Hydrochloride
Packaging: 50MG
Price: $680
Updated: 2025/07/31

Cayman Chemical

Product number: 23451
Product name: RS 127445 (hydrochloride)
Purity: ≥98%
Packaging: 1 mg
Price: $32
Updated: 2024/03/01

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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Chemical Properties,Usage,Production

Uses

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Biological Activity

in vivo

In rats, the fraction of RS-127445 that is bioavailable via the oral or intraperitoneal routes is 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5 mg/kg) produced plasma concentrations predicted to fully saturate accessible 5-HT_2B receptors for at least 4 h.RS-127445 (5 mg/kg) is administered to rats by oral, intraperitoneal and intravenous routes. Peak plasma concentrations are rapidly achieved with the highest concentrations being found at the first time-point measured following intravenous and intraperitonael administration (0.08 h) and by 0.25 h following dosing by the oral route of administration. RS-127445 is cleared from plasma with an estimated terminal elimination half-life of approximately 1.7 h. The bioavailability of RS-127445, when administered by the oral and intraperitoneal routes is approximately 14 and 62% of that obtained by intravenous administration. Approximately 60% of an intraperitoneal dose and 14% of the oral dose of RS-127445 (5 mg/kg) is bioavailable^[1]. RS-127445 (1-30 mg/kg), dose-dependently reduces faecal output, reaching significance at 10 and 30 mg/kg (n=6-11). In blood and brain, >98% of RS-127445 is protein-bound^[2].

IC 50

sPLA2: 5.5 (pKi); 5-HT₃ Receptor: <6 (pKi); 5-HT₅ Receptor: <6 (pKi); 5-HT₆ Receptor: <6 (pKi); 5-HT_2A Receptor: 6.3 (pKi); 5-HT_2C Receptor: 6.4 (pKi); 5-HT_2B Receptor: 9.5 (pKi)

storage

Desiccate at +4°C

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Suppliers

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17H16FN3HCl