ChemicalBook > CAS DataBase List > 3-OXO-PENTANENITRILE

3-OXO-PENTANENITRILE

Product Name
3-OXO-PENTANENITRILE
CAS No.
33279-01-5
Chemical Name
3-OXO-PENTANENITRILE
Synonyms
3-OXOPENTANONITRILE;3-OXO-PENTANENITRILE;Propionylacetonitrile;Pentanenitrile, 3-oxo-;cyanoMethyl ethyl ketone;Propanoylacetonitrile, 1-Cyanobutan-2-one
CBNumber
CB4262321
Molecular Formula
C5H7NO
Formula Weight
97.12
MOL File
33279-01-5.mol
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3-OXO-PENTANENITRILE Property

Boiling point:
30°C
Density 
0.956±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
10.37±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
T
RIDADR 
UN3276
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P839033
Product name
Propionylacetonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
463074
Product name
Propionylacetonitrile
Packaging
250mg
Price
$319
Updated
2021/12/16
Matrix Scientific
Product number
026306
Product name
3-Oxopentanenitrile
Purity
97%
Packaging
1g
Price
$39
Updated
2021/12/16
Matrix Scientific
Product number
026306
Product name
3-Oxopentanenitrile
Purity
97%
Packaging
5g
Price
$124
Updated
2021/12/16
AK Scientific
Product number
0486AE
Product name
3-Oxopentanenitrile
Packaging
5g
Price
$217
Updated
2021/12/16
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3-OXO-PENTANENITRILE Chemical Properties,Usage,Production

Uses

A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide β-?keto nitriles (Propionylacetonitrile) is reported.

Synthesis

105-37-3

33279-01-5

The general procedure for the synthesis of 3-oxopentanenitrile from ethyl propionate is as follows: - Acetonitrile (1.17 mL) was slowly added dropwise to a stirred n-butyllithium solution (1.6 M hexane solution, 14.06 mL) at -78 °C and stirred at this temperature for 1 hour. - Subsequently, ethyl propionate (1.5 mL) was added dropwise and the reaction mixture was slowly warmed to -45 °C, at which temperature stirring was continued for 2 hours. - Upon completion of the reaction, the mixture was acidified to pH 2 with aqueous 2N hydrochloric acid and then concentrated by evaporation. - The residue was extracted with dichloromethane and the combined organic phases were dried over magnesium sulfate, followed by evaporation of the solvent. - 3-Oxopentanenitrile was finally obtained in 80% yield. 1H NMR (CDCl3) δ: 1.14 (t, 3H), 2.66 (q, 2H), 3.46 (s, 2H).

References

[1] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 114
[2] Patent: WO2007/99335, 2007, A1. Location in patent: Page/Page column 96
[3] Patent: WO2007/99317, 2007, A1. Location in patent: Page/Page column 105
[4] Patent: US2002/32184, 2002, A1
[5] Patent: US2008/45496, 2008, A1. Location in patent: Page/Page column 15

3-OXO-PENTANENITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-OXO-PENTANENITRILE manufacturers

Career Henan Chemical Co
Product
3-OXO-PENTANENITRILE 33279-01-5
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

33279-01-5, 3-OXO-PENTANENITRILERelated Search:

Pivaloylacetonitrile CYCLOPENTANONE-2-CARBONITRILE 2-OXOCYCLOHEXANECARBONITRILE 4,4-DIMETHYL-5-OXO-PENTANENITRILE Valeronitrile 2-(2,2-DIMETHYLPROPANOYL)-3-(3-PHENOXYPHENYL)PROP-2-ENENITRILE 3-BENZO[3,4-D]1,3-DIOXOLEN-5-YL-2-(2,2-DIMETHYLPROPANOYL)PROP-2-ENENITRILE 2-(CYCLOPROPYLCARBONYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(4-HYDROXYPHENYL)PROP-2-ENENITRILE 3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)AMINO)-2-(2,2-DIMETHYLPROPANOYL)PROP-2-ENENITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(4-METHOXYPHENYL)PROP-2-ENENITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(4-HYDROXY-3-METHOXYPHENYL)PROP-2-ENENITRILE 3-(4-(DIMETHYLAMINO)PHENYL)-2-(2,2-DIMETHYLPROPANOYL)PROP-2-ENENITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(4-CHLOROPHENYL)PROP-2-ENENITRILE 2-(5-CHLORO(3-HYDROBENZIMIDAZOL-2-YLIDENE))-4,4-DIMETHYL-3-OXOPENTANENITRILE 3-(5,7-DIMETHYL-2-OXO(2H-CHROMEN-3-YL))-2-(2,2-DIMETHYLPROPANOYL)PROP-2-ENENITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(5-NITRO-2-(2-PYRIDYLTHIO)PHENYL)PROP-2-ENENITRILE 2-(2,2-DIMETHYLPROPANOYL)-3-(4-FLUOROPHENYL)PROP-2-ENENITRILE

  • 3-OXO-PENTANENITRILE
  • 3-OXOPENTANONITRILE
  • Propionylacetonitrile
  • Propanoylacetonitrile, 1-Cyanobutan-2-one
  • cyanoMethyl ethyl ketone
  • Pentanenitrile, 3-oxo-
  • 33279-01-5