3-OXO-PENTANENITRILE
- Product Name
- 3-OXO-PENTANENITRILE
- CAS No.
- 33279-01-5
- Chemical Name
- 3-OXO-PENTANENITRILE
- Synonyms
- 3-OXOPENTANONITRILE;3-OXO-PENTANENITRILE;Propionylacetonitrile;Pentanenitrile, 3-oxo-;cyanoMethyl ethyl ketone;Propanoylacetonitrile, 1-Cyanobutan-2-one
- CBNumber
- CB4262321
- Molecular Formula
- C5H7NO
- Formula Weight
- 97.12
- MOL File
- 33279-01-5.mol
3-OXO-PENTANENITRILE Property
- Boiling point:
- 30°C
- Density
- 0.956±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 10.37±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- T
- RIDADR
- UN3276
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P839033
- Product name
- Propionylacetonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 463074
- Product name
- Propionylacetonitrile
- Packaging
- 250mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- 026306
- Product name
- 3-Oxopentanenitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 026306
- Product name
- 3-Oxopentanenitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 0486AE
- Product name
- 3-Oxopentanenitrile
- Packaging
- 5g
- Price
- $217
- Updated
- 2021/12/16
3-OXO-PENTANENITRILE Chemical Properties,Usage,Production
Uses
A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide β-?keto nitriles (Propionylacetonitrile) is reported.
Synthesis
105-37-3
33279-01-5
The general procedure for the synthesis of 3-oxopentanenitrile from ethyl propionate is as follows: - Acetonitrile (1.17 mL) was slowly added dropwise to a stirred n-butyllithium solution (1.6 M hexane solution, 14.06 mL) at -78 °C and stirred at this temperature for 1 hour. - Subsequently, ethyl propionate (1.5 mL) was added dropwise and the reaction mixture was slowly warmed to -45 °C, at which temperature stirring was continued for 2 hours. - Upon completion of the reaction, the mixture was acidified to pH 2 with aqueous 2N hydrochloric acid and then concentrated by evaporation. - The residue was extracted with dichloromethane and the combined organic phases were dried over magnesium sulfate, followed by evaporation of the solvent. - 3-Oxopentanenitrile was finally obtained in 80% yield. 1H NMR (CDCl3) δ: 1.14 (t, 3H), 2.66 (q, 2H), 3.46 (s, 2H).
References
[1] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 114
[2] Patent: WO2007/99335, 2007, A1. Location in patent: Page/Page column 96
[3] Patent: WO2007/99317, 2007, A1. Location in patent: Page/Page column 105
[4] Patent: US2002/32184, 2002, A1
[5] Patent: US2008/45496, 2008, A1. Location in patent: Page/Page column 15
3-OXO-PENTANENITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
3-OXO-PENTANENITRILE Suppliers
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
- --
- Fax
- --
- jbarten@hfc-chemicals.com
- Country
- Germany
- ProdList
- 3132
- Advantage
- 38
View Lastest Price from 3-OXO-PENTANENITRILE manufacturers
- Product
- 3-OXO-PENTANENITRILE 33279-01-5
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-04