Nutlin-3b

Product Name: Nutlin-3b
CAS No.: 675576-97-3
Chemical Name: Nutlin-3b
Synonyms: CS-986;Nutlin-3b;9-trioxaundecane;11-Bis(tosyloxy)-3;NUTLIN-3B;NUTLIN 3B;Nutlin-3b USP/EP/BP;(+)-NUTLIN-3;NUTLIN 3B;Nutlin-3b - Nutlin-3, (+)-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
CBNumber: CB42624268
Molecular Formula: C30H30Cl2N4O4
Formula Weight: 581.49
MOL File: 675576-97-3.mol

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Nutlin-3b Property

Density: 1.36
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form: crystalline solid
pka: 14.35±0.20(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009816
Product name: (+)-Nutlin-3
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 10009816
Product name: (+)-Nutlin-3
Purity: ≥98%
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 10009816
Product name: (+)-Nutlin-3
Purity: ≥98%
Packaging: 10mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 10009816
Product name: (+)-Nutlin-3
Purity: ≥98%
Packaging: 25mg
Price: $536
Updated: 2024/03/01

TRC

Product number: N925530
Product name: Nutlin3b
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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Nutlin-3b Chemical Properties,Usage,Production

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC₅₀ value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

Uses

Nutlin 3b is a small molecule MDM2 antagonist.

Definition

ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.

References

[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.

Nutlin-3b Preparation Products And Raw materials

Raw materials

Preparation Products

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Nutlin-3b Suppliers

China 77 France 1 The Netherlands 1 United States 17 Global 96

MedChemexpress LLC

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Matrix Scientific

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View Lastest Price from Nutlin-3b manufacturers

Career Henan Chemical Co

Product: Nutlin-3b 675576-97-3
Price: US $1.00/g
Min. Order: 200KG
Purity: 99%
Supply Ability: 2tons
Release date: 2019-12-19

675576-97-3, Nutlin-3bRelated Search:

NUTLIN-3 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Imatinib mesylate Tozasertib Nutlin-3 Nutlin 3a ABT 263

Nutlin-3b

4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-

4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b

NUTLIN-3B;NUTLIN 3B

4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid

CS-986

4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

Nutlin-3b - Nutlin-3, (+)-

(+)-NUTLIN-3;NUTLIN 3B

Nutlin-3b USP/EP/BP

11-Bis(tosyloxy)-3

9-trioxaundecane

675576-97-3

677576-97-3

Inhibitors