AM095

Product Name: AM095
CAS No.: 1228690-36-5
Chemical Name: AM095
Synonyms: CS-1624;AM095 (free acid);AM-095 (free base);AM 095 (parent compound);AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID;[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid;2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid;[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-;(R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid;AM 095,Inhibitor,AM095 free acid,AM-095 free acid,inhibit,AM095,Lysophospholipid Receptor,AM-095,LPL Receptor
CBNumber: CB42624905
Molecular Formula: C27H24N2O5
Formula Weight: 456.49
MOL File: 1228690-36-5.mol

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AM095 Property

Boiling point:: 641.9±55.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; ≥42 mg/mL in DMSO; ≥8.12 mg/mL in H2O with ultrasonic
form: Powder
pka: 4.21±0.10(Predicted)
color: White to off-white

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22141
Product name: AM095
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22141
Product name: AM095
Purity: ≥98%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 22141
Product name: AM095
Purity: ≥98%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

ApexBio Technology

Product number: A3167
Product name: AM-095freebase
Packaging: 5mg
Price: $108
Updated: 2021/12/16

Apolloscientific

Product number: BISN0022
Product name: AM095FreeAcid
Purity: 98%
Packaging: 1mg
Price: $109
Updated: 2021/12/16

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AM095 Chemical Properties,Usage,Production

Biological Activity

am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].

in vitro

am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].

in vivo

am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].

target

LPA1 receptor

References

[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.

AM095 Preparation Products And Raw materials

Raw materials

Preparation Products

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AM095 Suppliers

China 60 India 1 The Netherlands 1 United States 13 Global 75

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
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TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
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View Lastest Price from AM095 manufacturers

Career Henan Chemical Co

Product: AM095 1228690-36-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 491
Release date: 2019-09-01

1228690-36-5, AM095Related Search:

N,N-DIETHYLBENZAMIDE Adenosine 2-Methylindole Octadecyl methacrylate

AM-095 (free base)

AM095 (free acid)

[4'-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid

AM 095 (parent compound)

2-[4-[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic Acid

AM 095;AM-095;AM-095 FREE ACID;AM 095 FREE ACID

CS-1624

[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-

AM 095,Inhibitor,AM095 free acid,AM-095 free acid,inhibit,AM095,Lysophospholipid Receptor,AM-095,LPL Receptor

(R)-2-(4'-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid

1228690-36-5

228690-36-5