AZ-505
- Product Name
- AZ-505
- CAS No.
- 1035227-44-1
- Chemical Name
- AZ-505
- Synonyms
- AZ-505;AZ-505 2TFA salt;AZ-505;AZ505;AZ 505;AZ505 (ditrifluoroacetate);N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate);N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)
- CBNumber
- CB42627355
- Molecular Formula
- C31H39Cl2F3N4O6
- Formula Weight
- 691.57
- MOL File
- 1035227-44-1.mol
AZ-505 Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥119.8 mg/mL in DMSO; ≥7.3 mg/mL in EtOH with ultrasonic
- form
- Powder
N-Bromosuccinimide Price
- Product number
- A808203
- Product name
- AZ505ditrifluoroacetate
- Packaging
- 2.5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- A808203
- Product name
- AZ505ditrifluoroacetate
- Packaging
- 5mg
- Price
- $415
- Updated
- 2021/12/16
- Product number
- BISN0120
- Product name
- AZ505 ditrifluoroacetate
- Packaging
- 10mg
- Price
- $432
- Updated
- 2021/12/16
- Product number
- CS-1734
- Product name
- AZ505ditrifluoroacetate
- Purity
- 99.99%
- Packaging
- 50mg
- Price
- $1188
- Updated
- 2021/12/16
- Product number
- B1256
- Product name
- AZ505ditrifluoroacetate
- Packaging
- 25mg
- Price
- $1335
- Updated
- 2021/12/16
AZ-505 Chemical Properties,Usage,Production
Uses
AZ505 is a potent inhibitor of SMYD2, which plays an important role in epigenetic signalling. Inhibiition of SMYD2 also functions as an activator of the tumor suppressor proteins.
Biological Activity
az505 is a potent set and mynd domain-containing 2 protein (smyd2) inhibitor that selectively inhibits the enzymatic activity of smyd2 (ic50: 0.12 μm) over a variety of other protein lysine methyltransferases (ic50 > 83.3 μμ), including smyd3, dot1l, ezh2, glp, g9a and set7/9 [1].az505 contains three distinct moieties: the benzooxazinone group which interacts with the lysine-binding channel of smyd2; the cyclohexyl group which interacts with the core set and i-set domains of smyd2; and the dichlorophenethyl group which extends across the peptide binding groove of smyd2 [1].the x-ray crystallographic analysis has revealed that az505 binds into the peptide binding groove of smyd2 competing with the peptide substrates [1].
AZ-505 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ-505 Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9254
- Advantage
- 55
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9926
- Advantage
- 65
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4662
- Advantage
- 60
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3238
- Advantage
- 58