AZD7545
- Product Name
- AZD7545
- CAS No.
- 252017-04-2
- Chemical Name
- AZD7545
- Synonyms
- CS-1842;AZD7545;AZD4575;AZD-7547;AZD 7547;AZD7547;AZD7545/AZD-7545;PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545;(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
- CBNumber
- CB42627360
- Molecular Formula
- C19H18ClF3N2O5S
- Formula Weight
- 478.87
- MOL File
- 252017-04-2.mol
AZD7545 Property
- Boiling point:
- 683.1±55.0 °C(Predicted)
- Density
- 1.473±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥15.63 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 10.39±0.29(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 5.33639
- Product name
- Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545 - CAS 252017-04-2 - Calbiochem
- Purity
- Pyruvate Dehydrogenase Kinase Inhibitor, AZD7545, CAS 252017-04-2, is a potent, selective, reversible inhibitor of PDHK2 (IC?? = 6.4 nM). Inhibits PDHK1 at higher levels (IC?? = 36.8 nM).
- Packaging
- 5MG
- Price
- $196
- Updated
- 2024/03/01
- Product number
- 19282
- Product name
- AZD 7545
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 19282
- Product name
- AZD 7545
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- 19282
- Product name
- AZD 7545
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 19282
- Product name
- AZD 7545
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $632
- Updated
- 2024/03/01
AZD7545 Chemical Properties,Usage,Production
Description
AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC50 value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC50s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC50 = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.
Definition
ChEBI: AZD7545 is a sulfone that is benzene substituted by [4-(dimethylcarbamoyl)phenyl]sulfonyl, chloro and [(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino groups at positions 1, 3 and 4, respectively. It is a potent and non-ATP-competitive inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2) with IC50 of 6.4 nM and exhibits glucose-lowering activity. Also inhibits PDHK1 at higher levels (IC50 = 36.8 nM). It has a role as a hypoglycemic agent and an EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor. It is a member of benzamides, a sulfone, a tertiary alcohol, a tertiary carboxamide, a secondary carboxamide, a member of monochlorobenzenes and an organofluorine compound.
target
PDHK2
References
[1] morrell j a, orme j, butlin r j, et al. azd7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. biochemical society transactions, 2003, 31(6): 1168-1170.
[2] mayers r m, butlin r j, kilgour e, et al. azd7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (pdhk2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) zucker rats. biochemical society transactions, 2003, 31(6): 1165-1167.
AZD7545 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AZD7545 manufacturers
- Product
- AZD7545 252017-04-2
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20