ChemicalBook > CAS DataBase List > FR901464

FR901464

Product Name: FR901464
CAS No.: 146478-72-0
Chemical Name: FR901464
Synonyms: WB 2663B;FR901464;PJKVJJDQXZARCA-QHYZBLTGSA-N;FR 901464|||FR-901464|||WB 2663B;(2S,3Z)-4-{[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dien-1-yl]-2,5-dimethyloxan-3-yl]carbamoyl}but-3-en-2-yl acetate;2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-
CBNumber: CB42627890
Molecular Formula: C27H41NO8
Formula Weight: 507.62
MOL File: 146478-72-0.mol

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FR901464 Property

storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (197.00 mM; Need ultrasonic)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3694
Product name: FR901464
Purity: ≥95% (HPLC)
Packaging: 1 unit
Price: $129
Updated: 2025/07/31

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FR901464 Chemical Properties,Usage,Production

Description

FR901464 is a potent anticancer moecule that lowers the mRNA levels of oncogenes and tumor suppressor genes.

Uses

FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1].

Definition

ChEBI: A spiro-epoxide with potent anticancer activity that lowers the mRNA levels of oncogenes and tumour supressor genes. It is isolated from Pseudomonas sp. no.2663.

References

[1] H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11. DOI:10.7164/antibiotics.49.1204
[2] Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709. DOI:10.1021/jo500800k

FR901464 Preparation Products And Raw materials

Raw materials

Preparation Products

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146478-72-0, FR901464Related Search:

FR901463 FR901465

FR901464

WB 2663B

PJKVJJDQXZARCA-QHYZBLTGSA-N

2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)-

FR 901464|||FR-901464|||WB 2663B

(2S,3Z)-4-{[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dien-1-yl]-2,5-dimethyloxan-3-yl]carbamoyl}but-3-en-2-yl acetate

146478-72-0