ChemicalBook > CAS DataBase List > 3,5-Di-tert-butylsalicylaldehyde

3,5-Di-tert-butylsalicylaldehyde

Product Name
3,5-Di-tert-butylsalicylaldehyde
CAS No.
37942-07-7
Chemical Name
3,5-Di-tert-butylsalicylaldehyde
Synonyms
3,5-DI-TERT-BUTYL-2-HYDROXYBENZALDEHYDE;3,5-DI-T-BUTYL-2-HYDROXYBENZALDEHYDE;Dapagliflozin Impurity 108;3,5-DI-TBUTYLSALICYLALDEHYDE;3,5- di Ding JishuiYang Quan;3,5-Di-tert-butylsalicylaldehyd;3,5-DI-TERT-BUTYLSALICYLALDEHYDE;3,5-di-tert-Butyl Salicylaldehtde;Ditert-butyl-2-hydroxybenzaldehyde;3,5-Bis(tert-butyl)salicylaldehyde
CBNumber
CB4262967
Molecular Formula
C15H22O2
Formula Weight
234.33
MOL File
37942-07-7.mol
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3,5-Di-tert-butylsalicylaldehyde Property

Melting point:
59-61 °C(lit.)
Boiling point:
277.6±35.0 °C(Predicted)
Density 
1.006±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO and methanol.
form 
Solid
pka
9.78±0.23(Predicted)
color 
Off-White to Light Yellow
Sensitive 
Air Sensitive
BRN 
1877810
InChIKey
RRIQVLZDOZPJTH-UHFFFAOYSA-N
CAS DataBase Reference
37942-07-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29124990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
140414
Product name
3,5-Di-tert-butyl-2-hydroxybenzaldehyde
Purity
99%
Packaging
5g
Price
$50.7
Updated
2024/03/01
Sigma-Aldrich
Product number
140414
Product name
3,5-Di-tert-butyl-2-hydroxybenzaldehyde
Purity
99%
Packaging
25g
Price
$61.4
Updated
2024/03/01
TCI Chemical
Product number
D2646
Product name
3,5-Di-tert-butylsalicylaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
D2646
Product name
3,5-Di-tert-butylsalicylaldehyde
Purity
>98.0%(GC)
Packaging
25g
Price
$38
Updated
2024/03/01
Alfa Aesar
Product number
B23834
Product name
3,5-Di-tert-butyl-2-hydroxybenzaldehyde, 99%
Packaging
5g
Price
$54.65
Updated
2024/03/01
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3,5-Di-tert-butylsalicylaldehyde Chemical Properties,Usage,Production

Chemical Properties

3,5-Di-tert-butylsalicylaldehyde is white to yellow powder or chunks or crystal or crystalline powder

Uses

3,5-Di-tert-butylsalicylaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-tert-butylsalicylaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).

Uses

3,5-Di-tert-butyl-2-hydroxybenzaldehyde is used in the synthesis of Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose, chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenyl acetylene to imines, chiral oxazolidine ligand for the enantioselective addition of diethyl zinc to aldehydes and tin Schiff base complexes with histidine analogues. It has antibacterial activity and is used in the preparation nickel complexes. It is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).

Uses

3,5-Di-tert-butyl-2-hydroxybenzaldehyde was used in the synthesis of

  • Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose
  • chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenylacetylene to imines
  • chiral oxazolidine ligand for the enantioselective addition of diethylzinc to aldehydes
  • tin Schiff base complexes with histidine analogues

Definition

ChEBI: 3,5-di-tert-butyl-2-hydroxybenzaldehyde is a hydroxybenzaldehyde.

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 1939, 1994 DOI: 10.1021/jo00086a062
Tetrahedron, 46, p. 793, 1990 DOI: 10.1016/S0040-4020(01)81362-4
Tetrahedron Letters, 13, p. 4205, 1972 DOI: 10.1016/S0040-4039(01)94276-5

General Description

3,5-Di-tert-butyl-2-hydroxybenzaldehyde undergoes condensation reaction with

  • methyl-2-{N-(2′-aminoethane)}-amino-1-cyclopentenedithiocarboxylate to yield Schiff base ligand
  • N,N-diethyl-2-methyl-1,4-phenylenediamine during the synthesis of copper(II) and cobalt(II) complexes of salicylaldimine

3,5-Di-tert-butylsalicylaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Di-tert-butylsalicylaldehyde Suppliers

INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from 3,5-Di-tert-butylsalicylaldehyde manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
3,5-Bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde 37942-07-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3,5-Di-tert-butylsalicylaldehyde 37942-07-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-10
Shaanxi Dideu Medichem Co. Ltd
Product
3,5-Di-tert-butylsalicylaldehyde 37942-07-7
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15

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