Saxagliptin hydrochloride

Product Name: Saxagliptin hydrochloride
CAS No.: 709031-78-7
Chemical Name: Saxagliptin hydrochloride
Synonyms: Saxaint-S;Saxagliptin HCL salt;Saxagliptin hydrochloride;(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride;(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrochloride;2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,monohydrochloride, (1S,3S,5S)-
CBNumber: CB42630096
Molecular Formula: C18H25N3O2.HCl
Formula Weight: 351.88
MOL File: 709031-78-7.mol

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Saxagliptin hydrochloride Property

Melting point:: >219°C
storage temp.: -20°C
solubility: Soluble in DMSO (20 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10?,11?,12-,13+,14+,15-,17?,18?;/s3
InChIKey: TUAZNHHHYVBVBR-PMEPUXBANA-N
SMILES: [C@@H](C12CC3CC(CC(C3)(O)C1)C2)(N)C(N1[C@@H](C[C@@H]2C[C@H]12)C#N)=O.Cl |&1:0,15,17,19,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H335May cause respiratory irritation

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23697
Product name: Saxagliptin (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 23697
Product name: Saxagliptin (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 23697
Product name: Saxagliptin (hydrochloride)
Packaging: 25mg
Price: $148
Updated: 2024/03/01

Cayman Chemical

Product number: 23697
Product name: Saxagliptin (hydrochloride)
Packaging: 50mg
Price: $276
Updated: 2024/03/01

Tocris

Product number: 6507
Product name: Saxagliptinhydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $395
Updated: 2021/12/16

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Saxagliptin hydrochloride Chemical Properties,Usage,Production

Description

Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2

Uses

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.

storage

Store at -20°C

References

Tahrani et al. (2009) Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus; Adv. Ther. 26 249 Augeri et al. (2005) Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes; J. Med. Chem. 48 5025

Saxagliptin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Saxagliptin hydrochloride Suppliers

China 93 India 9 Israel 1 United Kingdom 2 United States 9 USA 1 Global 115

Shanghai Boyle Chemical Co., Ltd.

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Adamas Reagent, Ltd.

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Dalian Meilun Biotech Co., Ltd.

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S.Z. PhyStandard Bio-Tech. Co., Ltd.

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View Lastest Price from Saxagliptin hydrochloride manufacturers

Career Henan Chemical Co

Product: Saxagliptin hydrochloride 709031-78-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

709031-78-7, Saxagliptin hydrochlorideRelated Search:

Carboxymethoxylamine hemihydrochloride BOC-DL-PROLINE ETHYL ESTER (1R,3S,5R)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXAMIDE 2,2,2-TRIFLUOROACETIC ACID (1S,3R,5S)-2-tert-Butyl 3-ethyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)- 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-aMino-2-tricyclo[3.3.1.13,7]dec-1-ylacetyl]-, (1S,3S,5S)- 1H-Pyrrole-1-carboxylic acid, 2-(aMinocarbonyl)-2,3-dihydro-, 1,1-diMethylethyl ester, (2S)- (S) - N- Boc- adamantylglycine (S)-1-Boc-2,3-dihydro-2-pyrrolecarboxylic acid ethyl ester 2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,5S)- N-Boc-L-trans-4,5-Methanoproline (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester (1S,3S,5S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID DSLXQSYLYSTVKT-ONZQNKQFSA-N 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3R,5S)- Saxagliptin O-β-D-glucuronide 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3S,5R)- N-Boc-L-trans-4,5-methanoproline ethyl ester

Saxagliptin hydrochloride

(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile monohydrochloride

(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

Saxagliptin HCL salt

Saxaint-S

2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,monohydrochloride, (1S,3S,5S)-

709031-78-7

C18H25N3O2HCl

Saxagliptin Hydrochloride