Tipiracil
- Product Name
- Tipiracil
- CAS No.
- 183204-72-0
- Chemical Name
- Tipiracil
- Synonyms
- CS-1684;Tipiracil;TAS-1-462;Tipiralacil;Tipiracil HCl;Tipiracil-001-HCl;Reaxys ID: 25670890;Tipiracil-13C-15N2 HCl;Tipiracil Impurity 4 HCl;Tipiracil Impurity 5 HCl
- CBNumber
- CB42666693
- Molecular Formula
- C9H12Cl2N4O2
- Formula Weight
- 279.12318
- MOL File
- 183204-72-0.mol
Tipiracil Property
- Melting point:
- 245℃ (decomposition)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly, Heated), Water (Slightly)
- form
- powder
- color
- white to beige
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1552
- Product name
- Tipiracil hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $146
- Updated
- 2023/06/20
- Product number
- SML1552
- Product name
- Tipiracil hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $584
- Updated
- 2023/06/20
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
Tipiracil Chemical Properties,Usage,Production
Description
Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.
Uses
Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.
Definition
ChEBI: A hydrochloride obtained by combining tipiracil with one equivalent of hydrochloric acid. Used in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer.
Biochem/physiol Actions
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.
target
thymidine phosphorylase
References
1. tsukihara h1, nakagawa f2, sakamoto k et al. efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, tas-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts. oncol rep. 2015 may;33(5):2135-42. 2. dexter dl, wolberg wh, ansfield fj, helson l and heidelberger c: the clinical pharmacology of 5-trifluoro-methyl-2'-deoxyuridine. cancer res 32: 247-253, 1972.3. fukushima m, suzuki n, emura t et al. structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides. biochem pharmacol 59: 1227-1236, 2000.
Tipiracil Preparation Products And Raw materials
Raw materials
Preparation Products
Tipiracil Suppliers
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View Lastest Price from Tipiracil manufacturers
- Product
- Tipiracil 183204-72-0
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99.5%min HPLC
- Supply Ability
- 10kgs
- Release date
- 2021-07-16
- Product
- Tipiracil 183204-72-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- Tipiracil 183204-72-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10