6-(Chloromethyl)uracil
- Product Name
- 6-(Chloromethyl)uracil
- CAS No.
- 18592-13-7
- Chemical Name
- 6-(Chloromethyl)uracil
- Synonyms
- Tipiracil-002;6-(CHLOROMETHYL;TIMTEC-BB SBB003961;Tipiracil Impurity 14;6-(CHLOROMETHYL)URACIL;4-(chloromethyl)uracil;5-CHLORO-6-METHYLURACIL;6-methyl-5-chlorouracil;6-Chloromethyluracil >6-(Chloromethyl)uracil,98%
- CBNumber
- CB6417853
- Molecular Formula
- C5H5ClN2O2
- Formula Weight
- 160.56
- MOL File
- 18592-13-7.mol
6-(Chloromethyl)uracil Property
- Melting point:
- 257 °C (dec.)(lit.)
- Density
- 1.393±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- almost transparency in N,N-DMF
- form
- powder to crystal
- pka
- 7.91±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C5H5ClN2O2/c6-2-3-1-4(9)8-5(10)7-3/h1H,2H2,(H2,7,8,9,10)
- InChIKey
- VCFXBAPEXBTNEA-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(CCl)=CC(=O)N1
- CAS DataBase Reference
- 18592-13-7(CAS DataBase Reference)
- EPA Substance Registry System
- 2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)- (18592-13-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 183946
- Product name
- 6-(Chloromethyl)uracil
- Purity
- 98%
- Packaging
- 5g
- Price
- $33.3
- Updated
- 2025/07/31
- Product number
- C1057
- Product name
- 6-Chloromethyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- C1057
- Product name
- 6-Chloromethyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $189
- Updated
- 2025/07/31
- Product number
- C381430
- Product name
- 6-(Chloromethyl)uracil
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- C381430
- Product name
- 6-(Chloromethyl)uracil
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
6-(Chloromethyl)uracil Chemical Properties,Usage,Production
Uses
6-(Chloromethyl)uracil is an alkali-resistant protein adsorbent, suitable for medical procedures. it is also used in the synthesis of chlorophenyl hydroxypiperidine analogs having anti-amylatic activity.
Synthesis
22126-44-9
18592-13-7
In a 250 mL three-necked flask, 6-(hydroxymethyl)uracil (11.5 g, 0.081 mol) was added, followed by 115 mL of dichloromethane, thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N,N-dimethylformamide in sequence. The reaction mixture was heated to reflux temperature and stirred continuously for 2 hours. After completion of the reaction, it was cooled to room temperature, the solid product was collected by filtration, washed with dichloromethane and dried to give 6-(chloromethyl)uracil (11.8 g, 90.8% yield).
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 70, p. 400 - 410
[2] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 367 - 373
[3] Patent: CN106831607, 2017, A. Location in patent: Paragraph 0049
[4] Patent: CN106892902, 2017, A. Location in patent: Paragraph 0099; 0100; 0101; 0102
6-(Chloromethyl)uracil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-(Chloromethyl)uracil manufacturers
- Product
- 6-Chloromethyluracil 18592-13-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 6-(Chloromethyl)uracil 18592-13-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 6-(ChloroMethyl)uracil 18592-13-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14