Tipiracil hydrochloride
- Product Name
- Tipiracil hydrochloride
- CAS No.
- 183204-72-0
- Chemical Name
- Tipiracil hydrochloride
- Synonyms
- CS-1684;TAS-1-462;Tipiralacil;Tipiracil HCl;Tipiracil-001-HCl;Reaxys ID: 25670890;Tipiracil-13C-15N2 HCl;Tibiracil Impurities 1;Tipiracil Impurity 5 HCl;Tipiracil Impurity 4 HCl
- CBNumber
- CB42666693
- Molecular Formula
- C9H12Cl2N4O2
- Formula Weight
- 279.12318
- MOL File
- 183204-72-0.mol
Tipiracil hydrochloride Property
- Melting point:
- 245℃ (decomposition)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly, Heated), Water (Slightly)
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 5mg/mL, clear (warmed)
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
- InChIKey
- KGHYQYACJRXCAT-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(CN2CCCC2=N)=C(Cl)C(=O)N1.[H]Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1552
- Product name
- Tipiracil hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $154
- Updated
- 2025/07/31
- Product number
- SML1552
- Product name
- Tipiracil hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $616
- Updated
- 2025/07/31
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 23319
- Product name
- Tipiracil (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
Tipiracil hydrochloride Chemical Properties,Usage,Production
Description
Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.
Uses
Tipiracil Hydrochloride serves as a treatment for metastatic colorectal cancer (mCRC). A thymidine phosphorylase inhibitor.
Definition
ChEBI: Tipiracil hydrochloride is a hydrochloride obtained by combining tipiracil with one equivalent of hydrochloric acid. Used in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. It has a role as an antineoplastic agent and an EC 2.4.2.4 (thymidine phosphorylase) inhibitor. It is a hydrochloride and an iminium salt. It contains a tipiracil(1+).
Biochem/physiol Actions
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.
target
thymidine phosphorylase
References
[1] MASAKAZU FUKUSHIMA . Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides[J]. Biochemical pharmacology, 2000, 59 10: Pages 1227-1236. DOI:10.1016/S0006-2952(00)00253-7.
[2] Kim, Y., Wower, J., Maltseva, N.I., et al. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun. Biol. 4(1), 193 (2021).
[3] HIROSHI TSUKIHARA. Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.[J]. Oncology reports, 2015, 33 5: 2135-2142. DOI:10.3892/or.2015.3876.
[4] D L DEXTER. The clinical pharmacology of 5-trifluoromethyl-2’-deoxyuridine.[J]. Cancer research, 1972, 32 2: 247-253.
Tipiracil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tipiracil hydrochloride Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from Tipiracil hydrochloride manufacturers
- Product
- Tipiracil 183204-72-0
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99.5%min HPLC
- Supply Ability
- 10kgs
- Release date
- 2021-07-16
- Product
- Tipiracil 183204-72-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- Tipiracil 183204-72-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10