ChemicalBook > CAS DataBase List > 11107B

11107B

Product Name
11107B
CAS No.
445493-23-2
Chemical Name
11107B
Synonyms
11107B;11107AD;PLADIENOLIDE B;SDOUORKJIJYJNW-VGQSKDSZSA-N;(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one;Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
CBNumber
CB42666916
Molecular Formula
C30H48O8
Formula Weight
536.7
MOL File
445493-23-2.mol
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11107B Property

Boiling point:
673.8±55.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A clear film
pka
13.98±0.70(Predicted)
color 
Colorless to off-white
InChIKey
SDOUORKJIJYJNW-QHOUZYGJSA-N
SMILES
O1[C@H](/C(/C)=C/C=C/[C@@H](C)C[C@@H]2[C@@H]([C@H](C)[C@@H](O)CC)O2)[C@@H](C)C=C[C@H](OC(C)=O)[C@@](O)(C)CC[C@@H](O)CC1=O |t:22|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16538
Product name
Pladienolide B
Purity
≥95%
Packaging
100μg
Price
$131
Updated
2026/04/30
Cayman Chemical
Product number
16538
Product name
Pladienolide B
Purity
≥95%
Packaging
500μg
Price
$491
Updated
2026/04/30
Cayman Chemical
Product number
16538
Product name
Pladienolide B
Purity
≥95%
Packaging
100μg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
16538
Product name
Pladienolide B
Purity
≥95%
Packaging
500μg
Price
$410
Updated
2024/03/01
Tocris
Product number
6070
Product name
PladienolideB
Purity
≥95%(HPLC)
Packaging
500U
Price
$371
Updated
2021/12/16
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11107B Chemical Properties,Usage,Production

Uses

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

Uses

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome.

in vivo

Pladienolide B (2.5-10 mg/kg; i.v.; daily for 5 days) has strong antitumor activities[4].

Animal Model:Female or male BALB/c nu/nu mice (7 weeks of age) (PC-3, OVCAR-3, DU-145, WiDr, and HCT-116, BSY-1 xenografts)[4]
Dosage:2.5, 5, and 10 mg/kg
Administration:I.v.; daily for 5 days
Result:Showed strong growth inhibitory or regressive activities against these xenografts.

storage

Store at -20°C

11107B Preparation Products And Raw materials

Raw materials

Preparation Products

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11107B Suppliers

China 32 United Kingdom 2 United States 3 USA 1 Global 38
Shanghai fuxiang biotechnology co., ltd
Tel
13611719524
Email
2674347328@qq.com
Country
China
ProdList
60
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58

445493-23-2, 11107BRelated Search:


  • 11107AD
  • 11107B
  • PLADIENOLIDE B
  • SDOUORKJIJYJNW-VGQSKDSZSA-N
  • (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
  • Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-
  • 445493-23-2