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Sitagliptin N-Boc IMpurity

Product Name
Sitagliptin N-Boc IMpurity
CAS No.
486460-23-5
Chemical Name
Sitagliptin N-Boc IMpurity
Synonyms
Sitagliptin-3;Boc-Sitagliptin;N-Boc-Sitagliptin;Sitagliptin N-Boc;Sitagliptin Impurity 56;Phenol,3-fluoro-8-iodo-;Sitagliptin Impurity 03;Sitagliptin N-Boc IMpurity;Sitagliptin EP Impurity 16;Sitagliptin N-Boc impurities
CBNumber
CB42675705
Molecular Formula
C21H23F6N5O3
Formula Weight
507.43
MOL File
486460-23-5.mol
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Sitagliptin N-Boc IMpurity Property

Melting point:
188-191 °C(Solv: toluene (108-88-3))
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Slightly)
pka
11.60±0.46(Predicted)
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B667500
Product name
N-Boc-Sitagliptin
Packaging
25mg
Price
$180
Updated
2021/12/16
Alichem
Product number
486460235
Product name
(R)-tert-Butyl(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
Packaging
5g
Price
$816
Updated
2021/12/16
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Sitagliptin N-Boc IMpurity Chemical Properties,Usage,Production

Uses

N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.

Sitagliptin N-Boc IMpurity Preparation Products And Raw materials

Raw materials

Preparation Products

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486460-23-5, Sitagliptin N-Boc IMpurityRelated Search:

1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)- Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 28 Sitagliptin phosphate monohydrate Sitagliptin N-Phoshate IMpurity Sitagliptin Impurity 27 Sitagliptin Sitagliptin Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin Impurity 14 (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid 2,4,5-Trifluorobenzaldehyde BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Sitagliptin Impurity 35 Sitagliptin impurity H HCl Sitagliptin Impurity 31 Sitagliptin N-Sulfate

  • Sitagliptin N-Boc IMpurity
  • Boc-Sitagliptin
  • tert-Butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate
  • Sitagliptin N-Boc
  • N-Boc-Sitagliptin
  • (R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
  • tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan- 2-yl)carbamate
  • Sitagliptin Impurity 56
  • Sitagliptin impurity 10/Sitagliptin N-Boc Impurity/tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
  • (R)-tert-butyl (4-oxo-4-(3-(trifluoromethyl)-
  • Sitagliptin-3
  • Sitagliptin Impurity 18 (Sitagliptin N-Boc Impurity)
  • Carbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethylester
  • Sitagliptin N-Boc impurities
  • Carbamic acid, N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester
  • tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-5H,6H,7H,8H-[ 1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorop henyl)butan-2-yl]carbamate
  • Sitagliptin EP Impurity 16
  • Carbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4...
  • Sitagliptin phosphate impurity 7
  • Phenol,3-fluoro-8-iodo-
  • Sitagliptin Impurity 03
  • Sitagliptin Impurity 18 tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5- trifluorophenyl)butan-2-yl)carbamate
  • (R)-[3-Oxo-1-(2,4,5-trifluoro-benzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-propyl]-carbamic acid tert-butyl ester
  • 486460-23-5