ChemicalBook > CAS DataBase List > 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide

4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide

Product Name
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
CAS No.
953769-46-5
Chemical Name
4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
Synonyms
BLZ945;106245;CS-1735;4-((2-(((1R;Sotuletinib;BLZ-945 >=95%;BLZ-945;BLZ 945;Sotuletinib (BLZ945);BLZ945 (Sotuletinib);Sotuletinib, 10 mM in DMSO
CBNumber
CB42706230
Molecular Formula
C20H22N4O3S
Formula Weight
398.48
MOL File
953769-46-5.mol
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4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Property

Density 
1.377±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥19.9 mg/mL in DMSO
form 
solid
pka
13.92±0.46(Predicted)
color 
Pale yellow
InChIKey
ADZBMFGQQWPHMJ-RHSMWYFYSA-N
SMILES
C1(C(NC)=O)=NC=CC(OC2C=C3SC(N[C@@H]4CCCC[C@H]4O)=NC3=CC=2)=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19626
Product name
BLZ-945
Purity
≥98%
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
19626
Product name
BLZ-945
Purity
≥98%
Packaging
5mg
Price
$407
Updated
2024/03/01
Cayman Chemical
Product number
19626
Product name
BLZ-945
Purity
≥98%
Packaging
10mg
Price
$648
Updated
2024/03/01
Cayman Chemical
Product number
19626
Product name
BLZ-945
Purity
≥98%
Packaging
50mg
Price
$2159
Updated
2024/03/01
TRC
Product number
B595835
Product name
BLZ945
Packaging
5mg
Price
$100
Updated
2021/12/16
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4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Chemical Properties,Usage,Production

Uses

BLZ945 is a tumor-associated macrophage targeting the treatment of glioblastoma multiforme, a most common type of aggresive brain cancer.

in vivo

Mice are treated with Sotuletinib or vehicle, and evaluated for symptom-free survival. Median survival in the vehicle-treated cohort is 5.7 weeks. In striking contrast, Sotuletinib significantly improves long-term survival. This endpoint is chosen because Ink4a/Arf / mice develop spontaneous tumors, including lymphomas and sarcomas, beginning at ~30 weeks. Sotuletinib is well-tolerated over long-term treatment, with no visible side-effects, consistent with histopathological studies. Histological grading revealed high-grade, invasive gliomas in all vehicle-treated mice. By contrast, Sotuletinib-treated animals have significantly less-malignant tumors, and no detectable lesions in 55.6% of asymptomatic mice at the endpoint[1]. Mice receiving Sotuletinib shows reduced CSF1R staining in both cervical tumors and the associated stroma, with a significant decrease in CSF1R+ stromal macrophages relative to vehicle-treated mice (P<0.05)[2].

storage

+4°C

4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide Suppliers

China 149 India 2 United Kingdom 2 United States 13 Global 166
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
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View Lastest Price from 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide manufacturers

Career Henan Chemical Co
Product
4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide 953769-46-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

953769-46-5, 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMideRelated Search:

Selumetinib Saracatinib Paclitaxel SR2516 INCB024360 17-AAG

  • 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
  • BLZ945
  • 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
  • 106245
  • BLZ-945;BLZ 945
  • CS-1735
  • 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide BLZ945
  • 4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide
  • BLZ-945 >=95%
  • 4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide
  • 2-Pyridinecarboxamide, 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-
  • 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide USP/EP/BP
  • 2R)-2-hydroxycyclohexyl)imino)-2
  • 3-dihydrobenzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide
  • 4-((2-(((1R
  • 4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methylpyridine-2-carboxamide
  • Sotuletinib
  • CSF1R,CSF-1R,CSF-1 receptor,inhibit,c-Fms,Inhibitor,colony stimulating factor 1 receptor,BLZ 945,Sotuletinib,BLZ-945
  • Sotuletinib (BLZ945)
  • Sotuletinib, 10 mM in DMSO
  • BLZ945 (Sotuletinib)
  • Sotuletinib (BLZ945) ，S7725
  • 953769-46-5
  • API
  • Inhibitors