MGL-3196

Product Name: MGL-3196
CAS No.: 920509-32-6
Chemical Name: MGL-3196
Synonyms: Resmetirom;CS-2429;VIA3196;MGL-3196;VIA-3196;Resmetirom(MGL-3196);MGL-3196(Resmetirom);Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CBNumber: CB42714673
Molecular Formula: C17H12Cl2N6O4
Formula Weight: 435.22
MOL File: 920509-32-6.mol

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MGL-3196 Property

Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:59.0(Max Conc. mg/mL);135.56(Max Conc. mM)
form: A crystalline solid
pka: 3.96±0.40(Predicted)
color: Yellow to orange
InChI: InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)
InChIKey: FDBYIYFVSAHJLY-UHFFFAOYSA-N
SMILES: N1=C(C#N)C(=O)NC(=O)N1C1=CC(Cl)=C(OC2=NNC(=O)C(C(C)C)=C2)C(Cl)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23845
Product name: MGL-3196
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0018402
Product name: MGL-3196
Purity: 95.00%
Packaging: 5MG
Price: $505.57
Updated: 2021/12/16

DC Chemicals

Product number: DC9995
Product name: MGL-3196(Resmetirom)
Purity: >98%
Packaging: 100mg
Price: $600
Updated: 2021/12/16

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MGL-3196 Chemical Properties,Usage,Production

Description

MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC₅₀s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC₅₀ = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

Uses

Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-beta agonist. It works by blocking the formation of fat in the liver and can be used to treat non-alcoholic steatohepatitis (NASH).

MGL-3196 Preparation Products And Raw materials

Raw materials

Preparation Products

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MGL-3196 Suppliers

China 180 India 2 United States 9 USA 1 Global 192

CHENGHUI PHARMACEUTICAL GROUP LTD

Tel: 0531-58897070 15254140813
Fax: 0531-58897046
Email: market@jnchsd.com
Country: China
ProdList: 213
Advantage: 58

Shandong Xuanshuo Pharmaceutical Technology Co. LTD

Tel: 15269103900
Email: suchangzhou@shiningpharm.com
Country: China
ProdList: 262
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Wuhan HSN Pharmaresearch CO., LTD.

Tel: 027-63499089 18086100502
Fax: 027-86589137
Email: linwell@126.com
Country: China
ProdList: 208
Advantage: 50

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 322
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151 15190133791;
Email: marketing@zenjipharma.com
Country: China
ProdList: 441
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151
Fax: 025-83172562
Email: marketing@zenjipharma.com
Country: China
ProdList: 441
Advantage: 58

Shandong Mingfeng Pharmaceutical and Technology Co. Ltd

Tel: -1345456643 15315114555
Fax: QQ:1345456643
Email: 1345456643@qq.com
Country: China
ProdList: 223
Advantage: 58

FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd

Tel: 25-8690-7345 18651693585
Email: zfx@farmasino.com
Country: China
ProdList: 129
Advantage: 58

Jinan Chenghui Shuangda biological Co., LTD

Tel: 0531-58897003 15550412551
Fax: 0531-58897003
Email: market@jnchsd.com
Country: China
ProdList: 211
Advantage: 62

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View Lastest Price from MGL-3196 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Resmetirom 920509-32-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-23

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: Resmetirom 920509-32-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 3 TONS
Release date: 2024-08-30

920509-32-6, MGL-3196Related Search:

Resmetirom (MGL-3196,VIA-3196)

MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196

VIA3196

VIA-3196

MGL-3196

Resmetirom

2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile

CS-2429

1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-

2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Resmetirom(MGL-3196)

MGL-3196(Resmetirom)

920509-32-6

C17H12Cl2N6O4

API