ChemicalBook > CAS DataBase List > Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
- Product Name
- Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
- CAS No.
- 877997-99-4
- Chemical Name
- Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
- Synonyms
- Acotiamide-020;Alcotimide intermediate 3;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazo;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-car...;Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester;4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester;2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester(for Acotiamide);4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester
- CBNumber
- CB42715504
- Molecular Formula
- C14H14N2O6S
- Formula Weight
- 338.34
- MOL File
- 877997-99-4.mol
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Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- M327138
- Product name
- Methyl2-(2-Hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
- Packaging
- 10mg
- Price
- $1320
- Updated
- 2021/12/16
AK Scientific
- Product number
- 6947EA
- Product name
- Methyl2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
- Packaging
- 10g
- Price
- $151
- Updated
- 2021/12/16
Ambeed
- Product number
- A393100
- Product name
- Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $5
- Updated
- 2021/12/16
Ambeed
- Product number
- A393100
- Product name
- Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $7
- Updated
- 2021/12/16
Ambeed
- Product number
- A393100
- Product name
- Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
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Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 2-?(2-?Hydroxy-?4,?5-?dimethoxybenzamido)?thiazole-?4-?carboxylate is an Acotiamide (A190260) impurity. Acotiamide is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction.
Synthesis
118452-04-3
5722-93-0
877997-99-4
The general procedure for the synthesis of methyl 2-(2-hydroxy-4,5-dimethoxybenzoylamino)thiazole-4-carboxylate from methyl 2-aminothiazole-4-carboxylate and 2-hydroxy-4,5-dimethoxybenzoic acid was as follows: 39.8 g (0.2 mol) 2-hydroxy-4,5-dimethoxybenzoic acid, 38 g (0.24 mol) 2-aminothiazole-4-carboxylate and 89.9 g (0.3 mol) 4,6-diphenoxy-2-chloro-1,3,5-triazine were suspended in a solution containing 800 mL of tetrahydrogen tetraoxide. methyl ester and 89.9 g (0.3 mol) 4,6-diphenoxy-2-chloro-1,3,5-triazine were suspended in a reaction flask containing 800 mL of tetrahydrofuran. A mixed solution consisting of 50.6 g (0.5 mol) N-methylmorpholine and 200 mL of tetrahydrofuran was added dropwise under stirring in an ice water bath. The dropwise addition was controlled to be completed within 20 min, after which stirring was continued for 1 h. The mixture was subsequently stirred for 2 h at room temperature. Stirring was stopped, the reaction solution was poured into water for pulping, crystallized in an ice bath, filtered and dried in vacuum to afford 65.1 g of methyl 2-(2-hydroxy-4,5-dimethoxybenzoylamino)thiazole-4-carboxylate as a white solid in 96.2% yield and 99.8% purity by HPLC.
References
[1] Patent: CN106316979, 2017, A. Location in patent: Paragraph 0050; 0051; 0052; 0053; 0054; 0055
Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate manufacturers
Henan Bao Enluo International TradeCo.，LTD
- Product
- Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate 877997-99-4
- Price
- US $100.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 500t/month
- Release date
- 2023-05-24
Hebei Mingeng Biotechnology Co., Ltd
- Product
- 4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester 877997-99-4
- Price
- US $280.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-12-21
Qiuxian Baitai New Material Co., LTD
- Product
- 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 877997-99-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000pcs
- Release date
- 2021-03-18
877997-99-4, Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylateRelated Search:
o-Terphenyl
AcotiaMide IMpurity 6 Maleate
Acotiamide-017
AcotiaMide IMpurity 9
acotiaMide iMpurity
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Acotiamide Impurity
AcotiaMide iMpurity 5
Methisosildenafil impure
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Terazosin EP Impurity O
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7,8-Dihydro-14-hydroxy- normorphinone
Donepezil Impurity
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
Sildenafil Chlorosulfonyl
diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate