7,8-Dihydro-14-hydroxy- normorphinone

Product Name: 7,8-Dihydro-14-hydroxy- normorphinone
CAS No.: 33522-95-1
Chemical Name: 7,8-Dihydro-14-hydroxy- normorphinone
Synonyms: (-)-Noroxymorphone;Naloxone EP Impurity A;7,8-Dihydro-14-hydroxynormorphinone;EN 3169;Noroxymorphone-d4;NoroxyMorphone HCl;Naloxone HCl Impurity;Naltrexone EP Impurity B;Naltrexone EP Impuirty B;Naltrexone Impurity 6 Monomer
CBNumber: CB5927506
Molecular Formula: C16H17NO4
Formula Weight: 287.32
MOL File: 33522-95-1.mol

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7,8-Dihydro-14-hydroxy- normorphinone Property

Melting point:: >265°C (dec.)
Boiling point:: 552.1±50.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
Flash point:: 22℃
storage temp.: Controlled Substance, -20°C Freezer
solubility: DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 9.20±0.40(Predicted)
Stability:: Hygroscopic
InChI: InChI=1/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/s3
InChIKey: HLMSIZPQBSYUNL-RSBMUYHFNA-N
SMILES: O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])NCC[C@@]23C4=5)O |&1:1,6,15,20,r|

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Safety

Hazard Codes: T,F
Risk Statements: 10-23/24/25-39/23/24/25-11
Safety Statements: 36/37-45-16-7
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1
DEA Controlled Substances: CSCN: 9668
CSA SCH: Schedule II
NARC: Yes

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N-012
Product name: Noroxymorphone hydrochloride solution
Purity: 1.0?mg/mL in methanol: DMSO (80:20) (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $293
Updated: 2025/07/31

Cayman Chemical

Product number: 15903
Product name: Noroxymorphone
Purity: ≥98%
Packaging: 1mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 15903
Product name: Noroxymorphone
Purity: ≥98%
Packaging: 5mg
Price: $469
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: MTB0002520
Product name: NOROXYMORPHONE
Purity: 95.00%
Packaging: 2.5MG
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0002520
Product name: NOROXYMORPHONE
Purity: 95.00%
Packaging: 25MG
Price: $1963.5
Updated: 2021/12/16

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7,8-Dihydro-14-hydroxy- normorphinone Chemical Properties,Usage,Production

Description

Noroxymorphone (Item No. 15903) is an analytical reference standard that is structurally categorized as an opioid. It is an active metabolite of oxycodone , noroxycodone (Item Nos. 15902 | 20407), and oxymorphone that can be detected in plasma and urine. Noroxymorphone is also an immediate precursor in the synthesis of several opioids, including naltrexone (Item Nos. 15520 | ISO60192) and naloxone (Item Nos. 15594 | ISO60191). Noroxymorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Off-White to Light Brown Solid

Uses

A metabolite of Naloxone and Naltrexone

Definition

ChEBI: Noroxymorphone is a member of phenanthrenes.

References

[1] CHAD M THOMPSON. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 308 2: 547-554. DOI: 10.1124/jpet.103.058602
[2] MERJA KOKKI. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine[J]. British journal of clinical pharmacology, 2016, 83 4: 791-800. DOI: 10.1111/bcp.13164
[3] TIMO KORJAMO. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.[J]. ACS Applied Energy Materials, 2012: 87. DOI: 10.3389/fphar.2011.00087
[4] BOJAN LALOVIC. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.[J]. ACS Applied Energy Materials, 2004: 447-454. DOI: 10.1124/dmd.32.4.447
[5] DR. BERNHARD GUTMANN. Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines—A Concise Synthesis of Noroxymorphone[J]. Chemistry - A European Journal, 2016, 22 30: 10393-10398. DOI: 10.1002/chem.201601902

7,8-Dihydro-14-hydroxy- normorphinone Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-Dihydro-14-hydroxy- normorphinone Suppliers

Canada 1 China 74 India 5 United States 6 Global 86

Chengdu Chuxin Pharmaceutical Technology Co., Ltd

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View Lastest Price from 7,8-Dihydro-14-hydroxy- normorphinone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 7,8-Dihydro-14-hydroxy- normorphinone 33522-95-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-21

Shaanxi Dideu Medichem Co. Ltd

Product: 7,8-Dihydro-14-hydroxy- normorphinone 33522-95-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-14

Career Henan Chemical Co

Product: (5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one 33522-95-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

33522-95-1, 7,8-Dihydro-14-hydroxy- normorphinoneRelated Search:

Sorafenib related coMpound 8 Posaconazole DiastereoisoMer interMediate 2 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE Benzoic acid 3-(2-Furyl)acrylic acid Nalfurafine 10α-Hydroxy-nalfurafine N-(3-Butenyl) NoroxyMorphone Hydrochloride Methisosildenafil impure Acotiamide Impurity Terazosin EP Impurity O Methisosildenafil Impurity Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Donepezil Impurity 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Sildenafil Chlorosulfonyl diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate

4,5α-Epoxy-3,14-dihydroxymorphinan-6-one

(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

NoroxyMorphone HCl

Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-, (5a)-

Noroxymorphone hydrochloride solution

Methanol(test NoroxymorphoneHCl,100μg/mLasfreebase)

Naloxone HCl Impurity

Naltrexone EP Impurity B

(4R,4aS,7aR,12bS)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one

Naltrexone EP Impuirty B

LTREXONE HYDROCHLORIDE - IMPURITY B

Naltrexone Impurity 6 Monomer

(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

(5a)-4,5-Epoxy-3,14-dihydroxy-morphinan-6-one

4-Hydroxydihydronormorphinone

7,8-Dihydro-14-hydroxy- normorphinone

7,8-Dihydro-14-hydroxynormorphinone

EN 3169

Naltrexone hydrochloride iMpurity B

Naloxone Impurity 7（Naloxone EP Impurity A）

Naloxone Hydrochloride Impurit Ⅰ:(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

Naloxone?Hydrochloride EP Impurity A

Naloxone EP Impurity A

Nor Oxymorphone (1.0mg/ml in DMSO)

Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5α)-

(-)-Noroxymorphone

Noroxymorphone-d4

4,5α-epoxy-3,14-dihydroxymorphinan-6-one (noroxymorphone)

Naltrexone EP Impurity B（Naloxone EP Impurity A）

(-)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

Naloxone EP Impurity A HCl (Noroxymorphone HCl)

33522-95-1

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals