ChemicalBook > CAS DataBase List > 7,8-Dihydro-14-hydroxy- normorphinone

7,8-Dihydro-14-hydroxy- normorphinone

Product Name: 7,8-Dihydro-14-hydroxy- normorphinone
CAS No.: 33522-95-1
Chemical Name: 7,8-Dihydro-14-hydroxy- normorphinone
Synonyms: (-)-Noroxymorphone;Naloxone EP Impurity A;7,8-Dihydro-14-hydroxynormorphinone;EN 3169;Noroxymorphone-d4;NoroxyMorphone HCl;Naloxone HCl Impurity;Naltrexone EP Impurity B;Naltrexone EP Impuirty B;Naltrexone Impurity 6 Monomer
CBNumber: CB5927506
Molecular Formula: C16H17NO4
Formula Weight: 287.32
MOL File: 33522-95-1.mol

Less

7,8-Dihydro-14-hydroxy- normorphinone Property

Melting point:: >265°C (dec.)
Boiling point:: 552.1±50.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
Flash point:: 22℃
storage temp.: Controlled Substance, -20°C Freezer
solubility: DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 9.20±0.40(Predicted)
Stability:: Hygroscopic
InChI: InChI=1/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/s3
InChIKey: HLMSIZPQBSYUNL-RSBMUYHFNA-N
SMILES: O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])NCC[C@@]23C4=5)O |&1:1,6,15,20,r|

Less

Safety

Hazard Codes: T,F
Risk Statements: 10-23/24/25-39/23/24/25-11
Safety Statements: 36/37-45-16-7
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1
DEA Controlled Substances: CSCN: 9668
CSA SCH: Schedule II
NARC: Yes

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N-012
Product name: Noroxymorphone hydrochloride solution
Purity: 1.0?mg/mL in methanol: DMSO (80:20) (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $293
Updated: 2025/07/31

Cayman Chemical

Product number: 15903
Product name: Noroxymorphone
Purity: ≥98%
Packaging: 1mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 15903
Product name: Noroxymorphone
Purity: ≥98%
Packaging: 5mg
Price: $469
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: MTB0002520
Product name: NOROXYMORPHONE
Purity: 95.00%
Packaging: 2.5MG
Price: $715
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0002520
Product name: NOROXYMORPHONE
Purity: 95.00%
Packaging: 25MG
Price: $1963.5
Updated: 2021/12/16

Less

7,8-Dihydro-14-hydroxy- normorphinone Chemical Properties,Usage,Production

Description

Noroxymorphone (Item No. 15903) is an analytical reference standard that is structurally categorized as an opioid. It is an active metabolite of oxycodone , noroxycodone (Item Nos. 15902 | 20407), and oxymorphone that can be detected in plasma and urine. Noroxymorphone is also an immediate precursor in the synthesis of several opioids, including naltrexone (Item Nos. 15520 | ISO60192) and naloxone (Item Nos. 15594 | ISO60191). Noroxymorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

Chemical Properties

Off-White to Light Brown Solid

Uses

A metabolite of Naloxone and Naltrexone

Definition

ChEBI: Noroxymorphone is a member of phenanthrenes.

References

[1] CHAD M THOMPSON. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 308 2: 547-554. DOI: 10.1124/jpet.103.058602
[2] MERJA KOKKI. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine[J]. British journal of clinical pharmacology, 2016, 83 4: 791-800. DOI: 10.1111/bcp.13164
[3] TIMO KORJAMO. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.[J]. ACS Applied Energy Materials, 2012: 87. DOI: 10.3389/fphar.2011.00087
[4] BOJAN LALOVIC. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.[J]. ACS Applied Energy Materials, 2004: 447-454. DOI: 10.1124/dmd.32.4.447
[5] DR. BERNHARD GUTMANN. Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines—A Concise Synthesis of Noroxymorphone[J]. Chemistry - A European Journal, 2016, 22 30: 10393-10398. DOI: 10.1002/chem.201601902

7,8-Dihydro-14-hydroxy- normorphinone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

7,8-Dihydro-14-hydroxy- normorphinone Suppliers

Canada 1 China 74 India 5 United States 6 Global 86

Chengdu Chuxin Pharmaceutical Technology Co., Ltd

Tel: 18782972721
Email: summer@earlyfaith.cn
Country: China
ProdList: 8
Advantage: 58

Anhui Yuanman Chemical Products Sales Co., Ltd.

Tel: 13816814028
Email: xena@yi-mu.com
Country: China
ProdList: 300
Advantage: 58

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Artis Chemistry (Shanghai) Co. Ltd.

Tel: 86-21-60936353
Fax: 86-21-60936352
Country: China
ProdList: 335
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

Artis Biotech Co. Ltd.

Tel: 028-67271278 18628360895
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 1960
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-50664929, 13971561712
Fax: 027-50664927 / QQ: 3452835437
Email: hubxys2001@163.com
Country: China
ProdList: 1437
Advantage: 55

Shanghai CR Corporation Limited

Tel: 13062833949; 4006653949 4006653949
Fax: QQ: 2136646215
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 9754
Advantage: 58

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2390
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Drjart Biological Co., Ltd.

Tel: 021-51736526 18616739945
Email: drjartchem@sina.com
Country: China
ProdList: 53
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 13316949107 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9564
Advantage: 58

Chengdu MassCale Pharmaceutical Co., Ltd.

Tel: 028-84552636 18084815636
Email: chensfsc@126.com
Country: China
ProdList: 1445
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15107
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 19925672674
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9883
Advantage: 12

Cangzhou Wanyou New Material Technology Co.,Ltd

Tel: 18631714998
Email: sales@czwytech.com
Country: CHINA
ProdList: 904
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-173 9270 1263
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3999
Advantage: 58

PCL - Business, Laboratory Pharmaceutical

Tel: 19150123681
Fax: QQ:3008022628
Email: Hu.xinyue@purechemland.com
Country: China
ProdList: 3566
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Shandong WorldSun Biological Technology Co., Ltd.

Tel: 0531-88723173 18596073690
Email: 1047208234@qq.com
Country: China
ProdList: 6780
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

Originchem Co., Ltd

Tel: 0523-0523-86200346 15996028822
Fax: 0523-86200341
Email: 1583458435@qq.com
Country: China
ProdList: 71
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3005
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9968
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171
Email: 3001025734@qq.com
Country: China
ProdList: 8880
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd

Tel: 013909357309 13909353777
Email: 419314657@qq.com
Country: China
ProdList: 2
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

PureChemland Co.,Ltd.

Tel: 13540909846 13882008651
Email: 3848291069@qq.com
Country: China
ProdList: 3001
Advantage: 58

Less

View Lastest Price from 7,8-Dihydro-14-hydroxy- normorphinone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 7,8-Dihydro-14-hydroxy- normorphinone 33522-95-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-21

Shaanxi Dideu Medichem Co. Ltd

Product: 7,8-Dihydro-14-hydroxy- normorphinone 33522-95-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-14

Career Henan Chemical Co

Product: (5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one 33522-95-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

33522-95-1, 7,8-Dihydro-14-hydroxy- normorphinoneRelated Search:

Sorafenib related coMpound 8 Posaconazole DiastereoisoMer interMediate 2 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE Benzoic acid 3-(2-Furyl)acrylic acid Nalfurafine 10α-Hydroxy-nalfurafine N-(3-Butenyl) NoroxyMorphone Hydrochloride Methisosildenafil impure Acotiamide Impurity Terazosin EP Impurity O Methisosildenafil Impurity Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Donepezil Impurity 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Sildenafil Chlorosulfonyl diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate

4,5α-Epoxy-3,14-dihydroxymorphinan-6-one

(5α)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

NoroxyMorphone HCl

Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-, (5a)-

Noroxymorphone hydrochloride solution

Methanol(test NoroxymorphoneHCl,100μg/mLasfreebase)

Naloxone HCl Impurity

Naltrexone EP Impurity B

(4R,4aS,7aR,12bS)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one

Naltrexone EP Impuirty B

LTREXONE HYDROCHLORIDE - IMPURITY B

Naltrexone Impurity 6 Monomer

(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

(5a)-4,5-Epoxy-3,14-dihydroxy-morphinan-6-one

4-Hydroxydihydronormorphinone

7,8-Dihydro-14-hydroxy- normorphinone

7,8-Dihydro-14-hydroxynormorphinone

EN 3169

Naltrexone hydrochloride iMpurity B

Naloxone Impurity 7（Naloxone EP Impurity A）

Naloxone Hydrochloride Impurit Ⅰ:(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

Naloxone?Hydrochloride EP Impurity A

Naloxone EP Impurity A

Nor Oxymorphone (1.0mg/ml in DMSO)

Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5α)-

(-)-Noroxymorphone

Noroxymorphone-d4

4,5α-epoxy-3,14-dihydroxymorphinan-6-one (noroxymorphone)

Naltrexone EP Impurity B（Naloxone EP Impurity A）

(-)-4,5-epoxy-3,14-dihydroxymorphinan-6-one

Naloxone EP Impurity A HCl (Noroxymorphone HCl)

33522-95-1

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals