Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate

Product Name: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
CAS No.: 877997-99-4
Chemical Name: Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
Synonyms: Acotiamide-020;Alcotimide intermediate 3;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazo;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-car...;Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester;4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester;2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester;2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester(for Acotiamide);4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester
CBNumber: CB42715504
Molecular Formula: C14H14N2O6S
Formula Weight: 338.34
MOL File: 877997-99-4.mol

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Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Property

storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M327138
Product name: Methyl2-(2-Hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

AK Scientific

Product number: 6947EA
Product name: Methyl2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate
Packaging: 10g
Price: $151
Updated: 2021/12/16

Chemenu

Product number: CM189491
Product name: methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
Purity: 97%
Packaging: 5g
Price: $262
Updated: 2021/12/16

Crysdot

Product number: CD11037270
Product name: Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
Purity: 97%
Packaging: 5g
Price: $277
Updated: 2021/12/16

Alichem

Product number: 877997994
Product name: Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate
Packaging: 5g
Price: $308
Updated: 2021/12/16

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Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 2-?(2-?Hydroxy-?4,?5-?dimethoxybenzamido)?thiazole-?4-?carboxylate is an Acotiamide (A190260) impurity. Acotiamide is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction.

Synthesis

118452-04-3

5722-93-0

877997-99-4

The general procedure for the synthesis of methyl 2-(2-hydroxy-4,5-dimethoxybenzoylamino)thiazole-4-carboxylate from methyl 2-aminothiazole-4-carboxylate and 2-hydroxy-4,5-dimethoxybenzoic acid was as follows: 39.8 g (0.2 mol) 2-hydroxy-4,5-dimethoxybenzoic acid, 38 g (0.24 mol) 2-aminothiazole-4-carboxylate and 89.9 g (0.3 mol) 4,6-diphenoxy-2-chloro-1,3,5-triazine were suspended in a solution containing 800 mL of tetrahydrogen tetraoxide. methyl ester and 89.9 g (0.3 mol) 4,6-diphenoxy-2-chloro-1,3,5-triazine were suspended in a reaction flask containing 800 mL of tetrahydrofuran. A mixed solution consisting of 50.6 g (0.5 mol) N-methylmorpholine and 200 mL of tetrahydrofuran was added dropwise under stirring in an ice water bath. The dropwise addition was controlled to be completed within 20 min, after which stirring was continued for 1 h. The mixture was subsequently stirred for 2 h at room temperature. Stirring was stopped, the reaction solution was poured into water for pulping, crystallized in an ice bath, filtered and dried in vacuum to afford 65.1 g of methyl 2-(2-hydroxy-4,5-dimethoxybenzoylamino)thiazole-4-carboxylate as a white solid in 96.2% yield and 99.8% purity by HPLC.

References

[1] Patent: CN106316979, 2017, A. Location in patent: Paragraph 0050; 0051; 0052; 0053; 0054; 0055

Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate Suppliers

China 89 India 1 United Kingdom 1 United States 5 Global 96

Adamas Reagent, Ltd.

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View Lastest Price from Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: Methyl2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate 877997-99-4
Price: US $100.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-05-24

Hebei Mingeng Biotechnology Co., Ltd

Product: 4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester 877997-99-4
Price: US $280.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-12-21

Qiuxian Baitai New Material Co., LTD

Product: 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 877997-99-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000pcs
Release date: 2021-03-18

877997-99-4, Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylateRelated Search:

o-Terphenyl AcotiaMide IMpurity 6 Maleate Acotiamide-017 AcotiaMide IMpurity 9 acotiaMide iMpurity AcotiaMide Related CoMpound (Ethyl 2-[(2-hydroxy-4,5-diMethoxybenzoyl)aMino]-4-Thiazolecarboxylate) Acotiamide Impurity AcotiaMide iMpurity 5 Methisosildenafil impure Acotiamide Impurity Terazosin EP Impurity O Methisosildenafil Impurity 7,8-Dihydro-14-hydroxy- normorphinone Donepezil Impurity 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Sildenafil Chlorosulfonyl diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate

Methyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate

2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester

2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic acid methyl ester

2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester(for Acotiamide)

Acotiamide-020

4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester

4-Thiazolecarboxylic acid, 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-, methyl ester

2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-car...

2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazo

Alcotimide intermediate 3

877997-99-4

877993-99-4