CX-4945 (sodiuM salt)

Product Name: CX-4945 (sodiuM salt)
CAS No.: 1309357-15-0
Chemical Name: CX-4945 (sodiuM salt)
Synonyms: CX-4945 Sodium;Silmitasertib sodium;CX-4945 (sodiuM salt);Silmitasertib sodium salt;Silmitasertib (CX-4945) Sodium;CX-4945 sodium salt(Silmitasertib);Silmitasertib (CX-4945)?sodium salt;Silmitasertib sodium salt, 10 mM in DMSO;Silmitasertib sodium salt,CX-4945 sodium salt;CX-4945 sodium salt (Silmitasertib sodium salt)
CBNumber: CB42735515
Molecular Formula: C19H13ClN3NaO2
Formula Weight: 373.77
MOL File: 1309357-15-0.mol

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CX-4945 (sodiuM salt) Property

storage temp.: Store at -20°C
solubility: H2O : 16.67 mg/mL (44.84 mM; Need ultrasonic)DMSO : 6.67 mg/mL (17.94 mM; Need ultrasonic)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3812
Product name: Silmitasertibsodiumsalt
Purity: 99.93%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-3812
Product name: Silmitasertibsodiumsalt
Purity: 99.93%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: SYN5664
Product name: CX-4945SodiumSalt
Packaging: 10mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-3812
Product name: Silmitasertibsodiumsalt
Purity: 99.93%
Packaging: 50mg
Price: $408
Updated: 2021/12/16

ApexBio Technology

Product number: B4903
Product name: CX-4945sodiumsalt
Packaging: 50mg
Price: $803
Updated: 2021/12/16

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CX-4945 (sodiuM salt) Chemical Properties,Usage,Production

Uses

Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.

in vivo

Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models^[1].

IC 50

CK2α: 1 nM (IC₅₀); CK2α': 1 nM (IC₅₀)

References

[1] Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. DOI:10.1158/0008-5472.CAN-10-1893
[2] Kendall JJ, et al. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin. Oncotarget. 2016 Aug 16;7(33):53191-53203. DOI:10.18632/oncotarget.10668
[3] Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. DOI:10.18632/oncotarget.6361
[4] Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70. DOI:10.3389/fphar.2015.00070

CX-4945 (sodiuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-4945 (sodiuM salt) Suppliers

China 49 United States 7 Global 56

Haoyuan Chemexpress Co., Ltd.

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