ChemicalBook > CAS DataBase List > Nivolumab

Nivolumab

Product Name
Nivolumab
CAS No.
946414-94-4
Chemical Name
Nivolumab
Synonyms
Opdivo;ONO 4538;MDX 1106;Nivolumab;BMS 936558;Nivolumab 10mg/ml;Nivolumab USP/EP/BP;Nivolumab (anti-PD-1);Research Grade Nivolumab(DHH02209)
CBNumber
CB42738187
Formula Weight
0
MOL File
Mol file
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Nivolumab Property

storage temp. 
Store at -80°C
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Safety

Hazardous Substances Data
946414-94-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0018408
Product name
ONO-4538
Purity
95.00%
Packaging
5MG
Price
$498.36
Updated
2021/12/16
ChemScene
Product number
CS-7489
Product name
Nivolumab
Purity
98.56%
Packaging
5mg
Price
$670
Updated
2021/12/16
Biosynth Carbosynth
Product number
BN164047
Product name
Nivolumab
Packaging
5mg
Price
$825
Updated
2021/12/16
Biosynth Carbosynth
Product number
BN164047
Product name
Nivolumab
Packaging
10mg
Price
$1500
Updated
2021/12/16
ChemScene
Product number
CS-7489
Product name
Nivolumab
Purity
98.56%
Packaging
1mg
Price
$280
Updated
2021/12/16
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Nivolumab Chemical Properties,Usage,Production

Mechanism of action

Nivolumab is a fully human, monoclonal IgG4 antibody that binds to programmed death-1 (PD-1) receptors with high specificity and affinity. PD-1 is expressed on T cells and dampens their immune response upon binding ligands PD-L1 and PD-L2 on APCs. This mechanism is pivotal to regulating central and peripheral tolerance. In cancer, aberrant PD-L1 expression by tumor cells or immune cells in the tumor microenvironment deactivates PD-1, expressing tumor-infiltrating lymphocytes, thereby allowing tumor cells to escape immune recognition and elimination. By inhibiting PD-1 function, nivolumab releases immune cells from pathological immune suppression, allowing them to recognize and counter tumor cells.

Clinical Use

Monoclonal antibody:
Treatment of advanced (unresectable or metastatic) melanoma, non-small cell lung cancer, renal cell carcinoma, classical Hodgkin lymphoma, squamous cell cancer of the head and neck and urothelial carcinoma

Side effects

The most common Immune-related adverse events (iRAEs) affect systems include the gastrointestinal and integumentary systems, usually manifesting as a pruritic rash, diarrhea, or colitis. When immune-mediated endocrine inflammation subdues, glandular function may be compromised, thus necessitating permanent hormone substitution. This includes nivolumab-induced hypothyroidism, hypopituitarism, adrenal insufficiency, and diabetes mellitus type 1.
Immune-mediated pneumonitis is a rare adverse effect associated with severe manifestations. Immune-related myocarditis is a very uncommon adverse event with high lethality. Less common adverse effects include ocular (uveitis, conjunctivitis, myositis of periocular muscles), inflammatory hepatitis, endocrinopathies such as hypothyroidism, hypopituitarism, and adrenal insufficiency. Other rare adverse events include those affecting the neurological system (encephalitis, Guillain-Barré syndrome).

Drug interactions

Potentially hazardous interactions with other drugs
Live vaccines: avoid concomitant use

Metabolism

The metabolic pathway of nivolumab has not been investigated. It is expected to be degraded into small peptides and amino acids via catabolic pathways in the same way as endogenous IgG

References

[1] Anthony V Serritella, Niraj K Shenoy. “Nivolumab Plus Ipilimumab vs Nivolumab Alone in Advanced Cancers Other Than Melanoma: A Meta-Analysis.” Jama Oncology (2023): 1441–1446.
[2] Jonathan Ho, C. Kelly, Erick A. Argueta. “S3644 Nivolumab-Induced Liver Injury.” American Journal of Gastroenterology (2021).
[3] Yang Wang. “Nivolumab combined docetaxel versus nivolumab in patients with previously treated nonsmall cell lung cancer: a phase 2 study.” Anti-Cancer Drugs (2024).

Nivolumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Nivolumab Suppliers

China 85 China Hong Kong 1 United Kingdom 1 United States 5 Global 92
Hefei Hirisun Pharmatech Co., Ltd.
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Chembest Research Laboratories Limited
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Wuhan Fortuna Chemical Co., Ltd
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TargetMol Chemicals Inc.
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LUCKY PHARMA CO., LIMITED
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AFINE CHEMICALS LIMITED
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DC Chemicals
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View Lastest Price from Nivolumab manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nivolumab 946414-94-4
Price
US $0.00/mg
Min. Order
1mg
Purity
99%~101%
Supply Ability
500g/month
Release date
2021-07-28
Dideu Industries Group Limited
Product
Nivolumab 946414-94-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Nivolumab 946414-94-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

946414-94-4, NivolumabRelated Search:

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  • Nivolumab
  • BMS 936558
  • MDX 1106
  • ONO 4538
  • Opdivo
  • Nivolumab (anti-PD-1)
  • Nivolumab USP/EP/BP
  • Nivolumab 10mg/ml
  • Research Grade Nivolumab(DHH02209)
  • 946414-94-4