SID 487795

Product Name: SID 487795
CAS No.: 203115-63-3
Chemical Name: SID 487795
Synonyms: NSC 617145;SID 487795;NSC-617145;WRN inhibitor;NSC 617145, 10 mM in DMSO;(2,3-Propandiyl-bis(2,3-dichloro)maleimide;NSC617145;NSC-617145;NSC 617145;WRN INHIBITOR;1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione;1,1'-(2,2-Dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione);1H-Pyrrole-2,5-dione, 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro- (9CI)
CBNumber: CB42750521
Molecular Formula: C13H10Cl4N2O4
Formula Weight: 400.04
MOL File: 203115-63-3.mol

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SID 487795 Property

Boiling point:: 451.5±45.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble3mg/mL, clear (warmed)
pka: -6.03±0.60(Predicted)
form: powder
color: white to light brown
InChI: 1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
InChIKey: PCOXPBOKDABARQ-UHFFFAOYSA-N
SMILES: ClC1=C(C(=O)N(C1=O)CC(CN2C(=O)C(=C(C2=O)Cl)Cl)(C)C)Cl

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1005
Product name: NSC 617145
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $139
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML1005
Product name: NSC 617145
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $525
Updated: 2026/03/19

Cayman Chemical

Product number: 21973
Product name: NSC 617145
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 21973
Product name: NSC 617145
Purity: ≥98%
Packaging: 5mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 21973
Product name: NSC 617145
Purity: ≥98%
Packaging: 10mg
Price: $133
Updated: 2024/03/01

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SID 487795 Chemical Properties,Usage,Production

Uses

NSC 617145 is ahelicase inhibitor used in the treatment of Werner syndrome helicase and acts synergistically with Mitomycin C (M371900), an antitumor antibiotic. It is used as antineoplastic.

Biological Activity

NSC 617145 has an IC50 value of 230nM.', 'NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) th at causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells.

storage

Store at -20°C

SID 487795 Preparation Products And Raw materials

Raw materials

Preparation Products

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SID 487795 Suppliers

China 60 United Kingdom 2 United States 7 USA 1 Global 70

Henan Alpha Chemical Co., Ltd.

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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203115-63-3, SID 487795Related Search:

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT 2-Amino-5-methylphenyl)phosphonic Acid 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- NSC228155 3-((Furan-2-ylmethyl)imino]-N,N-dimethyl-3H-1,2,4-dithiazol-5-amine Hydrobromide Nsc 617145

(2,3-Propandiyl-bis(2,3-dichloro)maleimide

1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione

NSC 617145

NSC-617145

SID 487795

NSC617145;NSC-617145;NSC 617145;WRN INHIBITOR

WRN inhibitor

1H-Pyrrole-2,5-dione, 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro- (9CI)

1,1'-(2,2-Dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione)

NSC 617145,breaks,NHEJ,helicase,DSB,abnormalities,WRN,DNA/RNA Synthesis,strand,Rad51,chromosomal,ATPase,Inhibitor,inhibit,double

3,4-dichloro-1-[3-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2,2-dimethylpropyl]-2,5-dihydro-1H-pyrrole-2,5-dione

NSC 617145, 10 mM in DMSO

203115-63-3

C13H10Cl4N2O4