8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT

Product Name: 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
CAS No.: 56932-43-5
Chemical Name: 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT
Synonyms: NSC 87877 sodium;NAPHTHYLAZOXINE S;NAPHTHYLAZOXINE 6S;NSC-87877 disodium;NSC-87877(sodium salt);nsc-87877 disodium salt;NSC87877/Naphthylazoxine6S;NAPHTHYLAZOXINE S DISODIUM SALT;NSC-87877 disodium, 10 mM in DMSO;SHP1/2 PTPase Inhibitor, NSC-87877
CBNumber: CB6408024
Molecular Formula: C19H11N3Na2O7S2
Formula Weight: 503.42
MOL File: 56932-43-5.mol

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8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Property

storage temp.: Inert atmosphere,Room Temperature
form: Solid
color: Brown to black
Water Solubility: water: 10mg/mL
EPA Substance Registry System: 5-Quinolinesulfonic acid, 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-, disodium salt (56932-43-5)

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Safety

Safety Statements: 24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565851
Product name: SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem
Packaging: 50MG
Price: $163
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: ING0002155
Product name: 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5- QUINOLINESULFONIC ACID DISODIUM SALT
Purity: 95.00%
Packaging: 1G
Price: $253.05
Updated: 2021/12/16

AK Scientific

Product number: 6404CA
Product name: Disodium8-hydroxy-7-[(6-sulphonato-2-naphthyl)azo]quinoline-5-sulphonate
Packaging: 1g
Price: $1173
Updated: 2021/12/16

Crysdot

Product number: CD30000062
Product name: NSC87877
Purity: 95%
Packaging: 25mg
Price: $60
Updated: 2021/12/16

Crysdot

Product number: CD30000062
Product name: NSC87877
Purity: 95%
Packaging: 50mg
Price: $102
Updated: 2021/12/16

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8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

dark red to red-brown powder

Uses

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

Biological Activity

Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively

in vivo

NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity^[3].

Animal Model:	Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice^[3].
Dosage:	30?mg/kg.
Administration:	IP once daily for 15 days.
Result:	Significantly inhibited NB tumor growth.

References

[1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207

8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT Suppliers

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56932-43-5, 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALTRelated Search:

(10-METHYL-9-ANTHRACENYL) CARBAMIMIDOTHIOIC ACID METHYL ESTER HYDROCHLORIDE 2-Amino-5-methylphenyl)phosphonic Acid SID 487795 NSC228155 3-((Furan-2-ylmethyl)imino]-N,N-dimethyl-3H-1,2,4-dithiazol-5-amine Hydrobromide 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)- 7-Aminoquinoline 2-Aminophenol-4-sulfonic acid 4-HYDROXYBENZENESULFONIC ACID SODIUM SALT HYDRATE 4-Hydroxybenzenesulfonic acid 8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT 8-Hydroxyquinoline-5-sulfonic acid 8-HYDROXYQUINOLINE-5-SULFONIC ACID MONOHYDRATE 4-HYDROXYBENZENESULFONIC ACID SODIUM SALT DIHYDRATE NAPHTHYLAZOXINE 8-HYDROXY-7-(4-SULFO-1-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID, DISODIUM SALT quinoline-5-sulphonic acid

5-Quinolinesulfonicacid,8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-,disodiumsalt

7-(6-Sulfo-2-naphthylazo)-8-hydroxyquinoline-5-sulfonicacid,disodiumsalt

NSC-87877(sodium salt)

8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonicacidisodium

7-(6-SULFO-2-NAPHTHYLAZO)-8-HYDROXYQUINOLINE-5-SULFONIC ACID SODIUM SALT

8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5-QUINOLINESULFONIC ACID DISODIUM SALT

NAPHTHYLAZOXINE 6S

NAPHTHYLAZOXINE S

disodium 8-hydroxy-7-[(6-sulphonato-2-naphthyl)azo]quinoline-5-sulphonate

nsc-87877 disodium salt

8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonic acid disodium

NAPHTHYLAZOXINE S DISODIUM SALT

8-Hydroxy-7-[(6-sulfo-2-naphthalenyl)-azo]-5-quinolinesulfonic acid disodiu

8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5- QUINOLINESULFONIC ACID DISODIUM SALT 98%

8-Hydroxy-7-(6-sodiooxysulfonyl-2-naphtylazo)quinoline-5-sulfonic acid sodium salt

8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt,98%

NSC 87877 sodium

NSC-87877 disodium

NSC87877/Naphthylazoxine6S

Sodium 8-hydroxy-7-((6-sulfonatonaphthalen-2-yl)diazenyl)quinoline-5-sulfonate

NSC-87877 disodium, 10 mM in DMSO

SHP1/2 PTPase Inhibitor, NSC-87877

56932-43-5

C19H11N3Na2O7S2

NaO3SC10H6NNC9H4NOHSO3Na