ChemicalBook > CAS DataBase List > 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- Product Name
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- CAS No.
- 1421312-34-6
- Chemical Name
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- Synonyms
- methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxadustat Impurity 34;Roxadustat impurity rst3;Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate;methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylat...
- CBNumber
- CB42756260
- Molecular Formula
- C18H15NO4
- Formula Weight
- 309.32
- MOL File
- 1421312-34-6.mol
More
Less
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Property
- Boiling point:
- 537.3±45.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere, 2-8°C
- pka
- 6.24±0.50(Predicted)
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
More
Less
N-Bromosuccinimide Price
AK Scientific
- Product number
- 2731DU
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Packaging
- 5g
- Price
- $593
- Updated
- 2021/12/16
Alichem
- Product number
- 1421312346
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Packaging
- 10g
- Price
- $614.8
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11260325
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Chemenu
- Product number
- CM263516
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $337
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11260325
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
More
Less
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.
Preparation
Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Suppliers
- Tel
- 0571-89081561; 10006559855
- Fax
- 0571 89081561
- info@cheminspire.com
- Country
- China
- ProdList
- 412
- Advantage
- 58
- Tel
- +86-571-85224801; 13588483690
- Fax
- 0571-85241599
- chemipanda2010@163.com
- Country
- China
- ProdList
- 109
- Advantage
- 62
- Tel
- +862136680027 15800370750
- sales@famobiotech.com
- Country
- China
- ProdList
- 509
- Advantage
- 56
- Tel
- 18268150871; 17302275155
- tanglulu11129@163.com
- Country
- China
- ProdList
- 28
- Advantage
- 58
- Tel
- 0592-6688068 18106901346
- Fax
- 0592-6686768
- qbl2015@halolife.cn
- Country
- China
- ProdList
- 94
- Advantage
- 55
- Tel
- 022-60182192,1339732154 18722583064
- Fax
- 86-22-60979672
- marketing@pharmacn.com
- Country
- China
- ProdList
- 112
- Advantage
- 61
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 025-58741518; 18013018875
- Fax
- +86-25-58744115
- sales@vcarepharmatech.com
- Country
- China
- ProdList
- 308
- Advantage
- 61
- Tel
- 027-027-83314682 13554138826
- Fax
- +86 (27) 8331-4682
- whsrtech@vip.163.com
- Country
- China
- ProdList
- 300
- Advantage
- 62
- Tel
- 021-021-37285271 15900820856
- Fax
- 021-37285512
- 83219210@qq.com
- Country
- China
- ProdList
- 89
- Advantage
- 57
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 850
- Advantage
- 58
- Tel
- 0556-5032870 15705561919
- Fax
- 0556-5032869
- sujuan.mei@nuoquanpharm.com
- Country
- China
- ProdList
- 96
- Advantage
- 55
- Tel
- 021-34666753 13311639313
- Fax
- +86-21-34979012
- info@shyrchem.com
- Country
- China
- ProdList
- 570
- Advantage
- 55
- Tel
- 021-021-58086325-8012-8012 13636568474
- Fax
- 021-51972827
- yingjie.zhang@suli.com
- Country
- China
- ProdList
- 103
- Advantage
- 58
- Tel
- 0512-62857507
- Fax
- +86-512-62857507
- sales@sinorarechem.com
- Country
- China
- ProdList
- 981
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17994
- Advantage
- 56
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9911
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5943
- Advantage
- 50
- Tel
- 025-66113011 18112977050
- cb6@aikonchem.com
- Country
- China
- ProdList
- 16687
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12357
- Advantage
- 58
- Tel
- 021-61984905-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6455
- Advantage
- 55
- Tel
- 021-58088081 Q3382968513
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 3151
- Advantage
- 55
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 5452
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 9038
- Advantage
- 58
- Tel
- 13761310616
- Fax
- QQ: 39324283
- 39324283@qq.com
- Country
- China
- ProdList
- 1950
- Advantage
- 58
- Tel
- 0531-68656072 15562569859
- Fax
- 0531-68656072
- 2921569326@qq.com
- Country
- China
- ProdList
- 57
- Advantage
- 55
- Tel
- 021-36680027/1762825045
- sales2@elestone.com.cn
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 13715524166 13326948089
- Fax
- +86 760 8866 5202
- resicn@resicn.com
- Country
- China
- ProdList
- 520
- Advantage
- 58
- Tel
- 021-37653318; 15221675714
- 515366396@qq.com
- Country
- China
- ProdList
- 2089
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- 15589964716
- Fax
- qq：3360232875
- 15253102672@163.com
- Country
- China
- ProdList
- 211
- Advantage
- 58
- Tel
- 021-68900963 15618693615
- Fax
- 021-68900963
- sales@jinghaopharma.com
- Country
- China
- ProdList
- 299
- Advantage
- 58
- Tel
- 0371-0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1029
- Advantage
- 58
- Tel
- +86-188369842 +86-15618151133
- Fax
- QQ188369842
- 188369842@qq.com
- Country
- China
- ProdList
- 1951
- Advantage
- 58
- Tel
- 18106139113
- Country
- China
- ProdList
- 201
- Advantage
- 58
- Tel
- 0755-22202135 13316968096
- 1979313431@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 58
- Tel
- 0576-88813233 13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 2013
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19785
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3967
- Advantage
- 58
- Tel
- 020-61855200 13326451905
- 2881290884@qq.com
- Country
- China
- ProdList
- 7497
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23556
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 12711
- Advantage
- 58
- Tel
- 0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25363
- Advantage
- 58
- Tel
- +86-571-86088112
- info@proserre.com
- Country
- China
- ProdList
- 1077
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12382
- Advantage
- 58
More
Less
View Lastest Price from 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester manufacturers
Hangzhou ICH Biofarm Co., Ltd
- Product
- 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester 1421312-34-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2023-06-30
Henan Aochuang Chemical Co.,Ltd.
- Product
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester 1421312-34-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13
Career Henan Chemical Co
- Product
- fg-4592 int 2 1421312-34-6
- Price
- US $5.50/KG
- Min. Order
- 2KG
- Purity
- 96%-99%
- Supply Ability
- 100kg
- Release date
- 2019-09-05
1421312-34-6, 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl esterRelated Search:
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester
Roxadustat
FG-4592 interMediate