ChemicalBook > CAS DataBase List > 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

Product Name
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
CAS No.
1421312-34-6
Chemical Name
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Synonyms
methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxastat intermediate;Roxadustat Impurity 34;Roxadustat Impurity N3;Roxadustat impurity rst3
CBNumber
CB42756260
Molecular Formula
C18H15NO4
Formula Weight
309.32
MOL File
1421312-34-6.mol
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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Property

Boiling point:
537.3±45.0 °C(Predicted)
Density 
1.289±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere, 2-8°C
pka
6.24±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
2731DU
Product name
Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
Packaging
5g
Price
$593
Updated
2021/12/16
Alichem
Product number
1421312346
Product name
Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
Packaging
10g
Price
$614.8
Updated
2021/12/16
Crysdot
Product number
CD11260325
Product name
Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
Purity
97%
Packaging
1g
Price
$120
Updated
2021/12/16
Chemenu
Product number
CM263516
Product name
Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
Purity
95+%
Packaging
5g
Price
$337
Updated
2021/12/16
Crysdot
Product number
CD11260325
Product name
Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
Purity
97%
Packaging
5g
Price
$360
Updated
2021/12/16
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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Usage,Production

Uses

4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.

Preparation

Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution.  Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Suppliers

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View Lastest Price from 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Roxadustat Impurity 26 1421312-34-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-07-17
Hangzhou ICH Biofarm Co., Ltd
Product
3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester 1421312-34-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-06-30
Henan Aochuang Chemical Co.,Ltd.
Product
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester 1421312-34-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-13

1421312-34-6, 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl esterRelated Search:

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester Roxadustat FG-4592 interMediate

  • fg-4592 int 2
  • methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
  • 1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate
  • Fg-4592/FG4592 int 2
  • ROXA-019
  • 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
  • methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate
  • 3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester
  • 4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid
  • Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate
  • Roxadustat Impurity 34
  • Fg6347
  • methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylat...
  • RSYY(Roxadustat)-17
  • Roxadustat impurity rst3
  • Roxastat intermediate
  • Roxadustat Impurity N3
  • 1421312-34-6
  • API