4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- Product Name
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- CAS No.
- 1421312-34-6
- Chemical Name
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
- Synonyms
- methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxastat intermediate;Roxadustat Impurity 34;Roxadustat Impurity N3;Roxadustat impurity rst3
- CBNumber
- CB42756260
- Molecular Formula
- C18H15NO4
- Formula Weight
- 309.32
- MOL File
- 1421312-34-6.mol
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Property
- Boiling point:
- 537.3±45.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere, 2-8°C
- pka
- 6.24±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 2731DU
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Packaging
- 5g
- Price
- $593
- Updated
- 2021/12/16
- Product number
- 1421312346
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Packaging
- 10g
- Price
- $614.8
- Updated
- 2021/12/16
- Product number
- CD11260325
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CM263516
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- CD11260325
- Product name
- Methyl4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.
Preparation
Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Suppliers
View Lastest Price from 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester manufacturers
- Product
- Roxadustat Impurity 26 1421312-34-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-07-17
- Product
- 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester 1421312-34-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2023-06-30
- Product
- 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester 1421312-34-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13