ChemicalBook > CAS DataBase List > ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE

ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE

Product Name: ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE
CAS No.: 72551-53-2
Chemical Name: ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE
Synonyms: ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE;Ethyl 1-benzyl-3-piperidinecarboxylate;Ethyl1-benzylpiperidine-3-carboxylate98%;1-Benzylpiperidine-3-carbonsSreethylester;Ethyl 1-benzylpiperidine-3-carboxylate 98%;Ethyl 1-(Phenylmethyl)-3-piperidinecarboxylate;1-Benzyl-piperidine-3-carboxylic acid ethal ester;1-BENZYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Piperidinecarboxylic acid, 1-(phenylMethyl)-, ethyl ester
CBNumber: CB4278210
Molecular Formula: C15H21NO2
Formula Weight: 247.33
MOL File: 72551-53-2.mol

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ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE Property

Boiling point:: 125-128°C 2mm
Density: 1.075±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: liquid
pka: 7.98±0.10(Predicted)
color: Colourless
CAS DataBase Reference: 72551-53-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P234Keep only in original container.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P390Absorb spillage to prevent material damage.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E899998
Product name: Ethyl1-benzylpiperidine-3-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: V7495
Product name: Ethyl1-benzylpiperidine-3-carboxylate
Packaging: 1g
Price: $14
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-W3
Product name: Ethyl 1-benzylpiperidine-3-carboxylate
Purity: 98%
Packaging: 1g
Price: $16
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-W3
Product name: Ethyl 1-benzylpiperidine-3-carboxylate
Purity: 98%
Packaging: 5G
Price: $76
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-W3
Product name: Ethyl 1-benzylpiperidine-3-carboxylate
Purity: 98%
Packaging: 25g
Price: $133
Updated: 2021/12/16

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ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

100-39-0

71962-74-8

72551-53-2

To a mixed solution of ethyl piperidine-3-carboxylate (5.94 mL, 38.24 mmol, 1.0 eq.) in dichloromethane (80 mL) and water (40 mL) was added benzyl bromide (4.77 mL, 1.05 eq.) and sodium carbonate (5.06 g, 1.25 eq.) in that order. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel, using ethyl acetate/hexane (1:6, v/v) as eluent, to afford ethyl 1-benzylpiperidine-3-carboxylate (9) as a colorless oil in 87% yield. 1H NMR (400 MHz, CDCl3) δ 7.29-7.18 (m, 5H, Ar-H), 4.11 (q, J = 7.2 Hz, 2H, OCH2CH3), 3.51 (d, J = 13.6 Hz, 1H, CHa-Ph), 3.44 (d, J = 13.2 Hz, 1H, CHb-Ph), 2.90 (m, 1H, Piperidine-H), 2.68 (m, 1H, Piperidine-H), 2.54 (m, 1H, Piperidine-H), 2.20 (m, 1H, Piperidine-H), 2.01 (m, 1H, Piperidine-H), 1.90 (m, 1H, Piperidine-H), 1.69 (m, 1H, Piperidine-H), 1.52 (m, 2H, Piperidine-H), 1.19 (t, J = 7.2 Hz, 3H, Piperidine-H), 3.44 (d, J = 13.2 Hz, 1H, CHb-Ph), 1.19 (t, J = 7.2 Hz, 3H, OCH2CH3). 13C NMR (62.5 MHz, CDCl3): δ 174.4, 138.4, 129.1, 128.2, 127.0, 63.3, 60.3, 55.5, 53.7, 42.0, 27.0, 24.6, 14.2; δ HRESI-MS m/z calcd for [M + H]+ C15H22NO2: 248.1645, found: 248.1646.

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 25, p. 5512 - 5532
[2] Journal of Organic Chemistry, 2016, vol. 81, # 22, p. 11235 - 11249
[3] Tetrahedron Letters, 2001, vol. 42, # 33, p. 5645 - 5649
[4] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 972 - 985
[5] Patent: US6664271, 2003, B1. Location in patent: Page column 15

ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE 72551-53-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 445
Release date: 2019-09-01

72551-53-2, ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATERelated Search:

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1-BENZYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER

ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE

1-Benzyl-piperidine-3-carboxylic acid ethal ester

Ethyl 1-benzylpiperidine-3-carboxylate 98%

1-Benzylpiperidine-3-carbonsSreethylester

Ethyl1-benzylpiperidine-3-carboxylate98%

3-Piperidinecarboxylic acid, 1-(phenylMethyl)-, ethyl ester

Ethyl 1-(Phenylmethyl)-3-piperidinecarboxylate

Ethyl 1-benzyl-3-piperidinecarboxylate

72551-53-2

C15H21NO2