4,5-Dichloro-2-octyl-isothiazolone
- Product Name
- 4,5-Dichloro-2-octyl-isothiazolone
- CAS No.
- 64359-81-5
- Chemical Name
- 4,5-Dichloro-2-octyl-isothiazolone
- Synonyms
- DCOIT;4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one;Sea-Nine 211;3(2H)-Isothiazolone, 4,5-dichloro-2-octyl-;C-9211;DCOIT-30;DCOIT-99;DCOIT 97;KATHON287;4,5-dichL
- CBNumber
- CB4279833
- Molecular Formula
- C11H17Cl2NOS
- Formula Weight
- 282.23
- MOL File
- 64359-81-5.mol
4,5-Dichloro-2-octyl-isothiazolone Property
- Melting point:
- 40.0 to 44.0 °C
- Boiling point:
- 322.6±52.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -6.09±0.60(Predicted)
- form
- Solid
- color
- White to Off-White
- Merck
- 14,3070
- Stability:
- Air Sensitive
- InChIKey
- PORQOHRXAJJKGK-UHFFFAOYSA-N
- CAS DataBase Reference
- 64359-81-5(CAS DataBase Reference)
- EPA Substance Registry System
- 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (64359-81-5)
Safety
- RIDADR
- 3077
- RTECS
- NX8157075
- HS Code
- 2934.10.7000
- HazardClass
- 9
- PackingGroup
- III
- Hazardous Substances Data
- 64359-81-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4157
- Product name
- 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- D435923
- Product name
- 4,5-Dichloro-2-octyl-3(2H)-isothiazolone
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD149298
- Product name
- 4,5-Dichloro-2-octyl-isothiazolone
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD149298
- Product name
- 4,5-Dichloro-2-octyl-isothiazolone
- Packaging
- 2g
- Price
- $575
- Updated
- 2021/12/16
- Product number
- 44963
- Product name
- 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $261.15
- Updated
- 2021/12/16
4,5-Dichloro-2-octyl-isothiazolone Chemical Properties,Usage,Production
Chemical Properties
Dichlorooctylisothiazolinone, DCOIT or DCOI, is an isothiazolinone compound. It is a white solid that melts at room temperature. It is an organic chemical that is slightly volatile and can dissolve in water. The measured K values show that DCOIT tends to move from water to octanol and has moderate to high lipophilicity.
Uses
Dichloroctylisothiazolinone is used as a broad spectrum biocide. It is used in paints especially marine coatings, decorative wood coatings and plastic industry. It is used primarily as a dry-film mildew protector for paint, coatings, paper, stains, plastics, wood, shoes, adhesives, metalworking fluids and printing inks. It is easily incorporated into water-based or solvent-based formulations.
Definition
ChEBI: 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone(DCOIT) is a 1,2-thiazole that is 1,2-thiazol-3(2H)-one substituted by chloro groups at positions 4 and 5 and an octyl group at position 2. It is used as a fungicide. It has a role as an environmental contaminant, a xenobiotic and a fungicide. It is an organochlorine compound and a member of 1,2-thiazoles.
Application
Suitable for applications in the paints and coatings, wood, and leather fields to resist corrosion and protect against mildews and algae.
Health Hazard
The chemical is referred to as 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in this assessment. Where available, data for two commercial antifouling products C-9211 HQ (32.6 % of DCOIT in xylene) and Acticide? DCOIT (97.1% purity) are used for some health end-points. The information on health hazards is primarily obtained from the comprehensive reviews from the Norwegian Environment Agency as part of its ECHA CLH proposal (ECHA, 2018) and an EU (Norway) DCOIT evaluation for the use of DCOIT as a biocide in antifouling products (EU, 2014). Unless otherwise noted, references to individual studies below are taken from these reviews.
Contact allergens
Irritant and sensitizer, Kathon? 930 caused contact dermatitis in employees of a textile fnishing factory.
Toxicology
The chemical, DCOIT is moderately absorbed through skin and moderately absorbed via oral route. It is then extensively distributed to tissues (liver, kidney, stomach and intestine) and metabolised following oral administration. In a study conducted in rats, 81–93 % of orally administered 14C-DCOIT was excreted primarily in the faeces within a 2-day period. Plasma elimination half-life of 14C-DCOIT was 16.1–19.4 hours for males and 20.5–25.0 hours for females. The highest concentration of 14C-DCOIT was found in liver, stomach, intestine and kidney. More than 80 % of the administered dose was eliminated via faeces, 11–18 % was eliminated via urine and less than 2 % of the dose was eliminated through exhaled air. DCOIT metabolised to form six metabolites in the faeces and eight metabolites in the urine. Degradation of DCOIT involves cleavage of the ring and subsequent oxidation of 7–18 % of the administrated dose to N-(n-octyl) malonamic acid (NNOMA, major metabolite), N-(n-octyl)acetamide, N-(n-octyl)oxamic acid and N-(n-octyl)-β-acetyl propionamide. The chemical undergoes subsequent biotransformation involving hydroxylation, dealkylation and acetylation (EU, 2014; ECHA, 2018).
Safety
The chemical and formulations containing the chemical applied to intact rabbit skin produced severe erythema, oedema and scar formation. The exposed areas had effects that were not reversible. Data indicates corrosive effects in the respiratory tract. While no data are available for effects in the eyes, the chemical is deemed to capable of causing severe damage. There is sufficient evidence to warrant hazard classification.
Synthesis
Add 200 g of ethyl acetate and 23.6 g (0.1 mol) of N,N'-dimethyl-3,3'-dithiodipropionamide into a 500ml four-neck flask equipped with a thermometer and a stirrer, stir and mix, and control The reaction temperature was 15° C., 1.8 g of thionyl chloride (15.1 mmol) was added to the four-neck flask, and the mixture was stirred for 10 min.21.3g (0.3mol) of chlorine gas was introduced into the reaction system, the mixture was stirred for 5h to react, and 27.1g of 4,5-Dichloro-2-octyl-isothiazolone was obtained by filtration and separation. The yield was 84.9%.
in vitro
In a bacterial gene mutation test, DCOIT was tested in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 up to a maximum concentration of 300 μg/plate with negative responses in all strains with and without metabolic activation (EU, 2014; ECHA, 2018).
in vivo
In two micronucleus assays, DCOIT was tested in CD-1 mice (5-9 mice/sex/dose) at doses up to 325 mg/kg bw/day by gavage. No genotoxicity was reported in both studies (EU, 2014; ECHA, 2018).
Precautions
1. Suitable for use in all marine paints. Can effectively kill many bacteria and mildews like penicillium notatum, basidiomycetes, aspergillus niger, fusarium, and curvularia. Can be added at any production step for use; it is recommended to adopt the concentration of 5 ~ 15% (w/w).2. Operational instruction must be strictly followed. Avoid any contact with the skin. Wear protective clothes, goggles, and rubber gloves in operation. Once any contact with the skin happens, wash the skin immediately with plenty of water and soaps; when it splashes into eyes, wash immediately with plenty of water and buffer solutions.
4,5-Dichloro-2-octyl-isothiazolone Preparation Products And Raw materials
Raw materials
Preparation Products
4,5-Dichloro-2-octyl-isothiazolone Suppliers
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 0536-8865336 13853655610
- Fax
- 86-536-5310398
- sophia@kaihongchem.com
- Country
- China
- ProdList
- 42
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3296
- Advantage
- 57
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 2002
- Advantage
- 62
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13358
- Advantage
- 58
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5877
- Advantage
- 58
- Tel
- +86-514-87325376 +86-514-87180828
- Fax
- +86-514-87325396 +86-514-87180928
- cy@crownyoung.com
- Country
- China
- ProdList
- 84
- Advantage
- 56
- Tel
- 0510-83593312 13665125081
- Fax
- 0510-83574508
- sales@honorshinechem.com
- Country
- China
- ProdList
- 52
- Advantage
- 60
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- +86-25-8331-5620
- Fax
- +86-25-8331-5629
- lanyachem@gmail.com
- Country
- China
- ProdList
- 435
- Advantage
- 55
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- 551-65418679 15837135945
- Fax
- 0551-65418697
- info@tnjchem.com
- Country
- China
- ProdList
- 1889
- Advantage
- 62
- Tel
- 028-88469284 18000562381
- rzbtsj@163.com
- Country
- China
- ProdList
- 9958
- Advantage
- 56
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20810
- Advantage
- 60
- Tel
- +86-86-27-85613400 +86-15827173649
- Fax
- 027-85613419
- info@silworldchemical.com
- Country
- China
- ProdList
- 313
- Advantage
- 58
- Tel
- 18126413629 0755-23311925 2355327053
- Fax
- 0755-23311925
- abel@ycgmp.com
- Country
- China
- ProdList
- 5115
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 18124570582 TEL：0755-23574479 2355327139
- Fax
- 0755-23229476 QQ: 2355327139
- siliao02@yccreate.com
- Country
- China
- ProdList
- 6120
- Advantage
- 58
- Tel
- 0551-65171243 13810511747
- kuer@kuerhuaxue.com
- Country
- China
- ProdList
- 2997
- Advantage
- 55
- Tel
- 18029243487 2355327168
- Fax
- 020-31121510
- gy@yccreate.com
- Country
- China
- ProdList
- 4753
- Advantage
- 55
- Tel
- 13127280945
- 285424065@qq.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- +86-21-5877 1921
- Fax
- +86-21-5877 1925
- info@chemofchina.com
- Country
- China
- ProdList
- 9661
- Advantage
- 55
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 1923
- Advantage
- 58
- Tel
- 18578209868 2355327026
- Fax
- 18578209868 QQ：2355327026
- steroidbest@hotmail.com
- Country
- China
- ProdList
- 6504
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15085
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17997
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24971
- Advantage
- 58
- Tel
- 18062666947
- Fax
- 18062666959
- 2355880548@qq.com
- Country
- China
- ProdList
- 4229
- Advantage
- 58
- Tel
- 0086-0551-62993905
- Fax
- 0086-0551-62993905
- info@hxygmall.com
- Country
- China
- ProdList
- 3374
- Advantage
- 58
- Tel
- 400-6387771-6038 18902104717
- sales@heowns.com
- Country
- China
- ProdList
- 20512
- Advantage
- 60
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 9693
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20569
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 0751-2815688 13927872512
- Fax
- 0751-8963795
- 3007421951@qq.com
- Country
- China
- ProdList
- 10071
- Advantage
- 58
- Tel
- 0731-85567275 19313119731
- sales@chemfish.com
- Country
- China
- ProdList
- 4918
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55827
- Advantage
- 58
- Tel
- 15926260361
- Fax
- QQ:1930063008
- 1930063008@qq.com
- Country
- China
- ProdList
- 5094
- Advantage
- 58
- Tel
- 021-58771921 13818686088
- Fax
- QQ: 3440059551
- info@chemofchina.com
- Country
- China
- ProdList
- 2989
- Advantage
- 58
- Tel
- 0371-55055611 18137792234
- Fax
- QQ：3002694073
- 3002694073@qq.com
- Country
- China
- ProdList
- 10162
- Advantage
- 58
- Tel
- 021-37590756
- Fax
- 021-57450128
- 373600283@qq.com
- Country
- China
- ProdList
- 5001
- Advantage
- 58
View Lastest Price from 4,5-Dichloro-2-octyl-isothiazolone manufacturers
- Product
- 4,5-Dichloro-2-octyl-isothiazolone 64359-81-5
- Price
- US $40.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-10
- Product
- 4,5-Dichloro-2-octyl-isothiazolone 64359-81-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-12-19
- Product
- 4,5-Dichloro-2-octyl-isothiazolone 64359-81-5
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000KG
- Release date
- 2023-09-05