2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

Product Name: 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
CAS No.: 76081-98-6
Chemical Name: 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
Synonyms: S28080;SCH 28080;SCH-28080,SCH28080;Schering compound 28080;imidazo-(1-2-a)pyrine-3-acetonitrile;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE
CBNumber: CB4281209
Molecular Formula: C17H15N3O
Formula Weight: 277.32
MOL File: 76081-98-6.mol

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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Property

Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10 mg/mL, soluble
form: solid
pka: 5.85±0.10(Predicted)
color: white to light tan

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4443
Product name: SCH-28080
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Sigma-Aldrich

Product number: S4443
Product name: SCH-28080
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $753
Updated: 2024/03/01

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Chemical Properties,Usage,Production

Description

SCH 28080 is a reversible K⁺-competitive inhibitor of H⁺/K⁺-ATPases that is best known for its ability to block acid secretion through its action against the gastric H⁺/K⁺-ATPase (IC₅₀ = 1.3 μM). It is effective against gastric H⁺/K⁺-ATPases from a variety of species and can inhibit colonic H⁺/K⁺-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H⁺/K⁺-ATPases in non-mammalian organisms and to distinguish the actions of H⁺/K⁺-ATPases from other ATP-dependent transporters.

Uses

SCH 28080 is a potent inhibitor of H+,K+-ATPase.

Definition

ChEBI: 2-(2-methyl-8-phenylmethoxy-3-imidazo[1,2-a]pyridinyl)acetonitrile is an imidazopyridine.

Biological Activity

Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

storage

Room temperature

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Suppliers

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76081-98-6, 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILERelated Search:

4(5)-CYANOMETHYLIMIDAZOLE 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE (1,4-DIMETHYL-1H-IMIDAZOL-2-YL)METHANOL 2-Methylimidazo[1,2-a]pyridin-8-ol 8-BENZYLOXY-IMIDAZO[1,2-A]PYRIDINE 3-Cyanomethyl-2-methylimidazo(1,2-a)pyridine (1-Methyl-1H-imidazol-2-yl)methanol Imidazo[1,2-a]pyridin-8-ol (9CI) IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE

3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile

Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-

S28080

Schering compound 28080

SCH 28080

imidazo-(1-2-a)pyrine-3-acetonitrile

SCH-28080,SCH28080

76081-98-6

Ion Pump Inhibitors

Ion Channels

Monovalent Ion Channels

Voltage-gated Ion Channels

BioChemical

Cell Signaling and Neuroscience

Cell Biology

ATPase