ChemicalBook > CAS DataBase List > 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

Product Name: 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
CAS No.: 76081-98-6
Chemical Name: 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
Synonyms: S28080;SCH 28080;SCH-28080,SCH28080;SCH28080, 10 mM in DMSO;Schering compound 28080;imidazo-(1-2-a)pyrine-3-acetonitrile;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;2-(8-(Benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-
CBNumber: CB4281209
Molecular Formula: C17H15N3O
Formula Weight: 277.32
MOL File: 76081-98-6.mol

Less

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Property

Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10 mg/mL, soluble
form: solid
pka: 5.85±0.10(Predicted)
color: white to light tan

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4443
Product name: SCH-28080
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $229
Updated: 2025/07/31

Sigma-Aldrich

Product number: S4443
Product name: SCH-28080
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $774
Updated: 2025/07/31

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17885
Product name: SCH 28080
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Less

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Chemical Properties,Usage,Production

Description

SCH 28080 is a reversible K⁺-competitive inhibitor of H⁺/K⁺-ATPases that is best known for its ability to block acid secretion through its action against the gastric H⁺/K⁺-ATPase (IC₅₀ = 1.3 μM). It is effective against gastric H⁺/K⁺-ATPases from a variety of species and can inhibit colonic H⁺/K⁺-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H⁺/K⁺-ATPases in non-mammalian organisms and to distinguish the actions of H⁺/K⁺-ATPases from other ATP-dependent transporters.

Uses

SCH 28080 is a potent inhibitor of H+,K+-ATPase.

Definition

ChEBI: 2-(2-methyl-8-phenylmethoxy-3-imidazo[1,2-a]pyridinyl)acetonitrile is an imidazopyridine.

Biological Activity

Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

storage

Room temperature

References

[1] W. BEIL K. Fr S I Hackbarth. Mechanism of gastric antisecretory effect of SCH 28080[J]. British Journal of Pharmacology, 1986, 88 1: 19-23. DOI: 10.1111/j.1476-5381.1986.tb09466.x
[2] B WALLMARK. Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.[J]. The Journal of Biological Chemistry, 1987, 262 5: 2077-2084.
[3] H G SWARTS. Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820.[J]. Molecular Pharmacology, 1999, 55 3: 541-547.
[4] JIAHONG SHAO . Pharmacological profiles of the murine gastric and colonic H,K-ATPases[J]. Biochimica et biophysica acta. General subjects, 2010, 1800 9: Pages 906-911. DOI: 10.1016/j.bbagen.2010.05.002
[5] WENDY S BEANE. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.[J]. Chemistry & biology, 2011, 18 1: 77-89. DOI: 10.1016/j.chembiol.2010.11.012
[6] SARAH A. SALYER . Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells[J]. Biochimica et biophysica acta. Molecular basis of disease, 2013, 1832 10: Pages 1734-1743. DOI: 10.1016/j.bbadis.2013.04.023

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Suppliers

China 56 Germany 2 Switzerland 1 United Kingdom 2 United States 11 USA 1 Global 73

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 965
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4809
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Guangzhou Taozhu Biotechnology Co., Ltd

Tel: 4008200310
Country: CHINA
ProdList: 111
Advantage: 58

Shanghai Shitang Industrial Co., Ltd.

Tel: 17301778918
Country: CHINA
ProdList: 105
Advantage: 58

Jinan Lemon Biotechnology Co., Ltd.

Tel: 138000000
Email: geans@163.com
Country: China
ProdList: 155
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Beijing Taize Ruida Technology Co., Ltd.

Tel: --
Fax: --
Email: taizeorder@163.com
Country: CHINA
ProdList: 6536
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6646
Advantage: 58

Shanghai Chaoyan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 471161314@qq.com
Country: CHINA
ProdList: 6210
Advantage: 58

Qingdao Jieshikang Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: jskangchina@163.com
Country: CHINA
ProdList: 4980
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6448
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6151
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

76081-98-6, 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILERelated Search:

4(5)-CYANOMETHYLIMIDAZOLE 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE (1,4-DIMETHYL-1H-IMIDAZOL-2-YL)METHANOL 2-Methylimidazo[1,2-a]pyridin-8-ol 8-BENZYLOXY-IMIDAZO[1,2-A]PYRIDINE 3-Cyanomethyl-2-methylimidazo(1,2-a)pyridine (1-Methyl-1H-imidazol-2-yl)methanol Imidazo[1,2-a]pyridin-8-ol (9CI) IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE

3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile

Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-

S28080

Schering compound 28080

SCH 28080

imidazo-(1-2-a)pyrine-3-acetonitrile

SCH-28080,SCH28080

2-(8-(Benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile

SCH28080, 10 mM in DMSO

76081-98-6

Ion Pump Inhibitors

Ion Channels

Monovalent Ion Channels

Voltage-gated Ion Channels

BioChemical

Cell Signaling and Neuroscience

Cell Biology

ATPase