BOC-L-Phenylglycinol
- Product Name
- BOC-L-Phenylglycinol
- CAS No.
- 117049-14-6
- Chemical Name
- BOC-L-Phenylglycinol
- Synonyms
- (S)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL;tert-butyl (S)-(2-hydroxy-1-phenylethyl)carbamate;BOC-PHG-OL;Boc-L-Phg-OL;CAS:117049-14-6;Boc-L-phenyglycol;BOC-PHENYLGLYCINOL;BOC-L-PHENYLGLYCINOL;TBOC-L-PHENYLGLYCINOL;Asciminib Impurity 19
- CBNumber
- CB4287458
- Molecular Formula
- C13H19NO3
- Formula Weight
- 237.29
- MOL File
- 117049-14-6.mol
BOC-L-Phenylglycinol Property
- Melting point:
- 136-139 °C(lit.)
- alpha
- +37°(19℃, c=1, CHCl3)
- Boiling point:
- 382.4±35.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 11.55±0.46(Predicted)
- color
- White to Orange to Green
- optical activity
- [α]19/D +37°, c = 1 in chloroform
- Water Solubility
- Insoluble in water.
- BRN
- 4316842
- InChIKey
- IBDIOGYTZBKRGI-LLVKDONJSA-N
- CAS DataBase Reference
- 117049-14-6(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29051990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 429821
- Product name
- (+)-N-Boc-L-α-phenylglycinol
- Purity
- 99%
- Packaging
- 1g
- Price
- $27.2
- Updated
- 2025/07/31
- Product number
- B3272
- Product name
- N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B3272
- Product name
- N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- B942813
- Product name
- (S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B942813
- Product name
- (S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
BOC-L-Phenylglycinol Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
N-Boc-L-alpha-phenylglycinol is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dye fields. Phenylglycinol-derived oxazolopiperidone lactams is used as starting materials for the enantioselective synthesis of piperidine-containing alkaloids.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
56613-80-0
67341-01-9
GENERAL STEPS: Di-tert-butyl dicarbonate (31.82 g, 146.8 mmol) was slowly added to a solution of anhydrous tetrahydrofuran (292 mL) containing (R)-(-)-2-phenylglycinol (20.00 g, 145.8 mmol) and triethylamine (24.4 mL, 175.0 mmol) at 0 °C. The reaction mixture was stirred continuously for 3 hours at 0 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (200 mL) and washed with 1N hydrochloric acid (240 mL). The aqueous layer was back-extracted with dichloromethane (2 x 100 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated again by rotary evaporator under reduced pressure to give a white solid product ((R)-tert-butyl 2-hydroxy-1-phenylethyl)carbamate (34.59 g, yield >99%). The product was characterized by 1H NMR (CDCl3): δ 1.43 (s, 9H), 2.29 (br s, 1H), 3.84-3.87 (m, 2H), 4.79 (br s, 1H), 7.29-7.39 (m, 5H).
References
[1] Tetrahedron Asymmetry, 2007, vol. 18, # 23, p. 2758 - 2767
[2] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 28
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[4] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
[5] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 38 - 42
BOC-L-Phenylglycinol Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-L-Phenylglycinol Suppliers
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- Country
- United Kingdom
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View Lastest Price from BOC-L-Phenylglycinol manufacturers
- Product
- Boc-L-Phg-Ol 117049-14-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-17
- Product
- BOC-L-Phenylglycinol 117049-14-6
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-16