BOC-L-Phenylglycinol

Product Name: BOC-L-Phenylglycinol
CAS No.: 117049-14-6
Chemical Name: BOC-L-Phenylglycinol
Synonyms: (S)-N-(TERT-BUTOXYCARBONYL)-2-PHENYLGLYCINOL;tert-butyl (S)-(2-hydroxy-1-phenylethyl)carbamate;BOC-PHG-OL;Boc-L-Phg-OL;CAS:117049-14-6;Boc-L-phenyglycol;BOC-PHENYLGLYCINOL;BOC-L-PHENYLGLYCINOL;TBOC-L-PHENYLGLYCINOL;Asciminib Impurity 19
CBNumber: CB4287458
Molecular Formula: C13H19NO3
Formula Weight: 237.29
MOL File: 117049-14-6.mol

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BOC-L-Phenylglycinol Property

Melting point:: 136-139 °C(lit.)
alpha: +37°(19℃, c=1, CHCl3)
Boiling point:: 382.4±35.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 11.55±0.46(Predicted)
color: White to Orange to Green
optical activity: [α]19/D +37°, c = 1 in chloroform
Water Solubility: Insoluble in water.
BRN: 4316842
InChIKey: IBDIOGYTZBKRGI-LLVKDONJSA-N
CAS DataBase Reference: 117049-14-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29051990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 429821
Product name: (+)-N-Boc-L-α-phenylglycinol
Purity: 99%
Packaging: 1g
Price: $27.2
Updated: 2025/07/31

TCI Chemical

Product number: B3272
Product name: N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B3272
Product name: N-(tert-Butoxycarbonyl)-L-2-phenylglycinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $88
Updated: 2025/07/31

TRC

Product number: B942813
Product name: (S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
Packaging: 500mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B942813
Product name: (S)-tert-Butyl(2-Hydroxy-1-phenylethyl)carbamate
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

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BOC-L-Phenylglycinol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

N-Boc-L-alpha-phenylglycinol is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dye fields. Phenylglycinol-derived oxazolopiperidone lactams is used as starting materials for the enantioselective synthesis of piperidine-containing alkaloids.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

56613-80-0

67341-01-9

GENERAL STEPS: Di-tert-butyl dicarbonate (31.82 g, 146.8 mmol) was slowly added to a solution of anhydrous tetrahydrofuran (292 mL) containing (R)-(-)-2-phenylglycinol (20.00 g, 145.8 mmol) and triethylamine (24.4 mL, 175.0 mmol) at 0 °C. The reaction mixture was stirred continuously for 3 hours at 0 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure by rotary evaporator. The concentrated residue was dissolved in dichloromethane (200 mL) and washed with 1N hydrochloric acid (240 mL). The aqueous layer was back-extracted with dichloromethane (2 x 100 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated again by rotary evaporator under reduced pressure to give a white solid product ((R)-tert-butyl 2-hydroxy-1-phenylethyl)carbamate (34.59 g, yield >99%). The product was characterized by 1H NMR (CDCl3): δ 1.43 (s, 9H), 2.29 (br s, 1H), 3.84-3.87 (m, 2H), 4.79 (br s, 1H), 7.29-7.39 (m, 5H).

References

[1] Tetrahedron Asymmetry, 2007, vol. 18, # 23, p. 2758 - 2767
[2] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 28
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
[4] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
[5] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 38 - 42

BOC-L-Phenylglycinol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-L-Phenylglycinol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Phg-Ol 117049-14-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-17

Career Henan Chemical Co

Product: BOC-L-Phenylglycinol 117049-14-6
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-16

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Asciminib Impurity 19

(+)-N-boc-L-alpha-phenylglycinol

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(+)-<i>N</i>-Boc-<sc>L</sc>-α-phenylglycinol

(+)-N-Boc-L-α-phenylglycinol

117049-14-6

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Peptide Synthesis

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