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2-FLUORO-5-METHOXYBENZONITRILE

Product Name
2-FLUORO-5-METHOXYBENZONITRILE
CAS No.
127667-01-0
Chemical Name
2-FLUORO-5-METHOXYBENZONITRILE
Synonyms
BUTTPARK 80\01-21;3-Cyano-4-fluoroanisole;6-Fluoro-m-anisonitrile;Fluoromethoxybenzonitrile;Fluoromethoxybenzonitrile2;2-fluoro-methoxybenzonitrile;2-FLUORO-5-METHOXYBENZONITRILE;2-Fluoro-5-methyloxybenzonitrile;Benzonitrile, 2-fluoro-5-methoxy-;2-Fluoro-5-methoxybenzonitrile98%
CBNumber
CB4293044
Molecular Formula
C8H6FNO
Formula Weight
151.14
MOL File
127667-01-0.mol
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2-FLUORO-5-METHOXYBENZONITRILE Property

Melting point:
77-80°C
Boiling point:
232.7±25.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Almost white
CAS DataBase Reference
127667-01-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
20/21/22-36/37/38-36/38
Safety Statements 
26-36/37/39-45-36/37
RIDADR 
3439
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000003
Product name
2-Fluoro-5-methoxybenzonitrile
Purity
Aldrich
Packaging
1g
Price
$42.8
Updated
2025/07/31
TCI Chemical
Product number
F0642
Product name
2-Fluoro-5-methoxybenzonitrile
Purity
>98.0%(GC)
Packaging
1g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
F0642
Product name
2-Fluoro-5-methoxybenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$109
Updated
2025/07/31
TRC
Product number
F599393
Product name
2-Fluoro-5-methoxybenzonitrile
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
F599393
Product name
2-Fluoro-5-methoxybenzonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
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2-FLUORO-5-METHOXYBENZONITRILE Chemical Properties,Usage,Production

Synthesis

796120-91-7

127667-01-0

The general procedure for the synthesis of 2-fluoro-5-methoxybenzonitrile from the compound (CAS: 796120-91-7) was as follows: 15 g of 2-fluoro-5-methoxybenzaldehyde oxime was dissolved in 150 mL of tetrahydrofuran, followed by the addition of 40 g of trifluoroacetic anhydride. 20 mL of triethylamine was slowly added under stirring. Upon completion of the reaction, the reaction mixture was concentrated to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate. The organic phase was separated, dried with anhydrous sodium sulfate, and then concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography to give 11 g of 2-fluoro-5-methoxybenzonitrile.

References

[1] Patent: CN107778264, 2018, A. Location in patent: Paragraph 0029; 0030
[2] Patent: CN107698535, 2018, A. Location in patent: Paragraph 0029; 0030
[3] Patent: CN108129415, 2018, A. Location in patent: Paragraph 0029-0030

2-FLUORO-5-METHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-5-METHOXYBENZONITRILE Suppliers

J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Alfa Aesar
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400-6106006
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021-67582001/03/05
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TCI (Shanghai) Development Co., Ltd.
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Sales-CN@TCIchemicals.com
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Shijiazhuang Sdyano Fine Chemical Co., Ltd.
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Wuhan Chemwish Technology Co., Ltd
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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View Lastest Price from 2-FLUORO-5-METHOXYBENZONITRILE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-FLUORO-5-METHOXYBENZONITRILE 127667-01-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-10-24
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-FLUORO-5-METHOXYBENZONITRILE 127667-01-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Career Henan Chemical Co
Product
2-FLUORO-5-METHOXYBENZONITRILE 127667-01-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12