Description References
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Lafutidine

Description References
Product Name
Lafutidine
CAS No.
118288-08-7
Chemical Name
Lafutidine
Synonyms
Stogar;LACTITOL;frg-8813;Protecadin;LAFUTIDINE;Laflutidine;Lafurtidine;118288-08-07;enyl)acetamide;Lafutidine API
CBNumber
CB4297653
Molecular Formula
C22H29N3O4S
Formula Weight
431.55
MOL File
118288-08-7.mol
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Lafutidine Property

Melting point:
92.7-94.9°
Boiling point:
704.2±60.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Water Solubility 
Insoluble in water
solubility 
DMF:5.0(Max Conc. mg/mL);11.59(Max Conc. mM)
DMSO:48.67(Max Conc. mg/mL);112.77(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.21(Max Conc. mM)
Ethanol:9.0(Max Conc. mg/mL);20.86(Max Conc. mM)
form 
powder to crystal
pka
13.13±0.46(Predicted)
color 
White to Orange to Green
CAS DataBase Reference
118288-08-7(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
L0341
Product name
Lafutidine
Packaging
25MG
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
L0341
Product name
Lafutidine
Packaging
1G
Price
$273
Updated
2024/03/01
Cayman Chemical
Product number
30275
Product name
Lafutidine
Packaging
25mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
30275
Product name
Lafutidine
Packaging
50mg
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
L0341
Product name
Lafutidine
Packaging
250MG
Price
$100
Updated
2024/03/01
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Lafutidine Chemical Properties,Usage,Production

Description

Lafutidine is a second generation of H2-receptor antagonist. H2-receptor antagonist can strongly inhibit gastric acid secretion compared with conventional drugs such as antacids. Unlike conventional H2-receptor antagonist, lafutidine inhibits gastric acid secretion during daytime as well as nighttime in clinical studies in humans. Lafutidine also has gastroprotective activity independent of its acid antisecretory efficacy, preventing noxious agent-induced gastric mucosal injury and accelerating the repair process following gastric mucosal damage. It also protects experimentally induced reflux esophagitis, indomethacin-induced intestinal, and dextran sulfate sodium-induced colonic inflammation.
Lafutidine is used for gastric and duodenal ulcers. It is also confirmed that lafutidine can be used as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia.

References

[1] Tomohiko Shimatani, Masaki Inoue, Tomoko Kuroiwa, Jing Xu, Masuo Nakamura, Susumu Tazuma, Kazuro Ikawa, Norifumi Morikawa (2006) Lafutidine, a Newly Developed Antiulcer Drug, Elevates Postprandial Intragastric pH and Increases Plasma Calcitonin Gene-Related Peptide and Somatostatin Concentrations in Humans: Comparisons with Famotidine, Digestive Diseases and Sciences, 51, 114-120
[2] Bhupesh Dewan, Nisha Philipose (2011) Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial, Gastroenterology Research and Practice, 2011, Article ID 640685
[3] https://www.drugs.com

Description

Lafutidine was launched in Japan for the treatment of gastritis, reflux oesophagitis and peptic ulcers. It can be prepared in eight steps from 4-(2-tetrahydropyranyloxy)-2(Z)-butenl- ol. Lafutidine is a potent and longer-acting H2 antagonist compared to other marketed compounds of its class such as cimetidine and famotidine. In contrast to other commercially available H2 antagonists, lafutidine also exerts a gastroprotective action probably via capsaicin-sensitive afferent nerves. It was clinically effective in the treatment of nonsteroidal antiinflammatory drug-induced ulcer in patients refractory to existing antiulcer agents.

Description

Lafutidine is a histamine H2 receptor antagonist with gastroprotective activity. It inhibits histamine-induced cAMP production in CHO cells expressing human histamine H2 receptors when used at a concentration of 10 nM. Intragastric administration of lafutidine (3, 10, and 30 mg/kg) reduces hemorrhagic esophageal lesion size and gastric acid secretion in a rat model of pyloric ligation-induced reflux esophagitis. It prevents 5-fluorouracil-induced intestinal mucositis, diarrhea, and body weight loss in wild-type, but not Trpv1-/- or sensory deafferented, mice when administered at doses ranging from 3 to 30 mg/kg. Lafutidine (10 mg/kg) also reduces indomethacin-induced antral ulcer size in wild-type, but not chemically-deafferented, rats.

Originator

Fujirebio (Japan)

Uses

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide is a Histaminic H2 receptor antagonists in ulcer disease. Also, it is a model compound used to investigate the binding mechanism between antiulcer drugs and human serum albumin (HSA).

Uses

Second generation histamine H2-receptor antagonist. Antiulcerative

Uses

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion

Definition

ChEBI: Lafutidine is an organic molecular entity.

brand name

Stogar, Protecadin

Lafutidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Lafutidine Suppliers

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LGM Pharma
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View Lastest Price from Lafutidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lafutidine 118288-08-7
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
98.5%min
Supply Ability
10kg
Release date
2021-11-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lafutidine 118288-08-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lafutidine 118288-08-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

118288-08-7, LafutidineRelated Search:

Omeprazole Famotidine Ranitidine Lafutidine N-{4-[4-(PIPERIDINOMETHYL)PYRIDYL-2-OXY]-CIS-2-BUTENE}PHTHALIMIDE MALEIC ACID(INTERMEDIATE FOR LAFUTIDINE) LACTITOL MONOHYDRATE,LACTITOL H2O,D-LACTITOL MONOHYDRATE,LACTITOL MONOHYDRATE 99% p-Nitrophenyl 2-(Furfurylsulfinyl)acetate 4-[4-(Piperidinomethyl)pyridyl-2-oxy]-cis-2-butenamine 2-ALLYLOXYPYRIDINE LACTITOL (Z)-4-[(TETRAHYDRO-2H-PYRAN-2-YL)OXY]-2-BUTEN-1-OL (PREPARATION FOR LAFUTIDINE) Lomerizine Furan Acetamide 2-Butene 2(1H)-Pyridinone,4-(aminomethyl)-(9CI) 2-((FURAN-2-YL)METHYLSULFINYL)-N-((Z)-4-HYDROXYBUT-2-ENYL)ACETAMIDE N-(PYRIDIN-4-YLMETHYL)BUTAN-1-AMINE

  • n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide
  • 2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide
  • (Z)-2-((Furan-2-ylMethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylMethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetaMide
  • Adefovir Dipivioxil
  • (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)
  • (Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-
  • LAFUTIDINE(SUBJECTTOPATENTFREE)
  • 118288-08-07
  • LACTITOL
  • 2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide
  • Laflutidine
  • Protecadin
  • Stogar
  • 2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)4-[[4-(1-piperidinylmethyl)-2-pyridinyl] oxy]-2-butenyl]-acetamide
  • LAFUTIDINE
  • (+-)-2-(furfurylsulfinyl)-n-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(z)-2-but
  • (z)-inyl)oxy)-2-butenyl)
  • acetamide,2-((2-furanylmethyl)sulfinyl)-n-(4-((4-(1-piperidinylmethyl)-2-pyrid
  • enyl)acetamide
  • frg-8813
  • 2-(2-furanylmethylsulfinyl)-N-[2-hydroxy-4-[4-(4-piperidinylmethyl)-2-pyridinyl]but-1-enyl]acetamide
  • Lafutidine Lafutidine
  • (Z)-2-[(Furan-2-ylmethyl)sulfinyl]-N-[4-[[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy]but-2-en-1-yl]acetamide
  • Lafutidine USP/EP/BP
  • 2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide
  • (+)-(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((4-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide
  • Lafutidine (FRG-8813)
  • LafutidineQ: What is Lafutidine Q: What is the CAS Number of Lafutidine Q: What is the storage condition of Lafutidine Q: What are the applications of Lafutidine
  • Lafutidine API
  • R)-Palonosetron Hydrochloride
  • Lafutidine Tablets
  • Lafurtidine
  • 118288-08-7
  • 118288-89-7
  • 118288-08-07
  • 118288-08-1
  • 18288-08-7
  • C22H29N3O4S
  • Other APIs
  • Active Pharmaceutical Ingredients
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds