ChemicalBook > CAS DataBase List > N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide

Product Name
N,N'-Diisopropylcarbodiimide
CAS No.
693-13-0
Chemical Name
N,N'-Diisopropylcarbodiimide
Synonyms
DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution
CBNumber
CB4301572
Molecular Formula
C7H14N2
Formula Weight
126.2
MOL File
693-13-0.mol
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N,N'-Diisopropylcarbodiimide Property

Melting point:
210-2120C (dec)
Boiling point:
145-148 °C(lit.)
Density 
0.815 g/mL at 20 °C(lit.)
vapor pressure 
34.9hPa at 55.46℃
refractive index 
n20/D 1.433(lit.)
Flash point:
93 °F
storage temp. 
Store below +30°C.
solubility 
Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form 
Liquid
color 
Clear colorless to yellow
Sensitive 
Moisture Sensitive
BRN 
878281
Stability:
Volatile
InChIKey
BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP
4.11 at 20℃
CAS DataBase Reference
693-13-0(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System
2-Propanamine, N,N'-methanetetraylbis- (693-13-0)
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Safety

Hazard Codes 
T+,T,F,Xn
Risk Statements 
10-26-36/37/38-41-42/43-37/38
Safety Statements 
26-36/37/39-45-38-28A-16-22
RIDADR 
UN 2929 6.1/PG 1
WGK Germany 
3
RTECS 
FF2175000
F 
10-21
Hazard Note 
Flammable/Highly Toxic/
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29252000
Hazardous Substances Data
693-13-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03649
Product name
N,N′-Diisopropylcarbodiimide
Purity
for synthesis
Packaging
10ml
Price
$51.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03649
Product name
N,N′-Diisopropylcarbodiimide
Purity
for synthesis
Packaging
25mL
Price
$99.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03649
Product name
N,N′-Diisopropylcarbodiimide
Purity
for synthesis
Packaging
100mL
Price
$261
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03649
Product name
N,N′-Diisopropylcarbodiimide
Purity
for synthesis
Packaging
1L
Price
$1170
Updated
2024/03/01
Sigma-Aldrich
Product number
38370
Product name
DIC
Purity
purum, ≥98.0% (GC)
Packaging
25ml
Price
$89.6
Updated
2024/03/01
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N,N'-Diisopropylcarbodiimide Chemical Properties,Usage,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. In addition to this, it is used in the synthesis of acid anhydride, aldehyde, ketone and isocyanate.

Uses

This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane N,N'-DIISOPROPYLTHIOUREA

Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE
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View Lastest Price from N,N'-Diisopropylcarbodiimide manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
N,N'-Diisopropylcarbodiimide 693-13-0
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-09
Hebei Zhuanglai Chemical Trading Co Ltd
Product
N,N'-Diisopropylcarbodiimide 693-13-0
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-22
hebei hongtan Biotechnology Co., Ltd
Product
N,N'-Diisopropylcarbodiimide 693-13-0
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-26

693-13-0, N,N'-DiisopropylcarbodiimideRelated Search:

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  • DIC
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  • N,N'-DIISOPROPYLCARBODIIMIDE, CHEMDOSE &
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  • N,N'-Diisopropylcarbodidimide
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