ChemicalBook > CAS DataBase List > PFK-158

PFK-158

Product Name
PFK-158
CAS No.
1462249-75-7
Chemical Name
PFK-158
Synonyms
PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
CBNumber
CB43034954
Molecular Formula
C18H11F3N2O
Formula Weight
328.29
MOL File
1462249-75-7.mol
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PFK-158 Property

Boiling point:
466.3±45.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form 
A crystalline solid
pka
2.46±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3145
Product name
PFK-158
Purity
≥98% (HPLC)
Packaging
5MG
Price
$86.8
Updated
2023/06/20
Sigma-Aldrich
Product number
SML3145
Product name
PFK-158
Purity
≥98% (HPLC)
Packaging
25MG
Price
$280
Updated
2023/06/20
Cayman Chemical
Product number
22987
Product name
PFK158
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
22987
Product name
PFK158
Purity
≥95%
Packaging
10mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
22987
Product name
PFK158
Purity
≥95%
Packaging
25mg
Price
$220
Updated
2024/03/01
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PFK-158 Chemical Properties,Usage,Production

Description

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

PFK-158 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFK-158 Suppliers

China 58 United States 6 Global 64
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

1462249-75-7, PFK-158Related Search:

PFK-015 Silver

  • PFK-158
  • PFK-158, ACT-PFK-158
  • (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one
  • PFK-158;PFK 158
  • PFK-158 free base
  • 2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-
  • (E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one
  • p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
  • (E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one
  • 1462249-75-7
  • 1462249-75-1
  • C18H11F3N2O