N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Product Name: N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide
CAS No.: 1474110-21-8
Chemical Name: N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide
Synonyms: CS-2157;GSK2981278;ROR gamma GS2981278;ROR gama modulator 1;GSK-2981278;GSK 2981278;ROR GAMA MODULATOR 1;N-(4-Ethyl-phenyl)-3-hydroxymethyl-N-isobutyl-4-(tetrahydro-pyran-4-ylmethoxy)-benzenesulfonamide;N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide;N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide;Benzenesulfonamide, N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-;IL-22,ointment,RAR-related orphan receptor,psoriasis,topically,GSK2981278,GSK 2981278,inflammation,il17,inverse,binding,IL-17A,ROR,inhibit,RORγ-DNA,Inhibitor,GSK-2981278
CBNumber: CB43037591
Molecular Formula: C25H35NO5S
Formula Weight: 461.61
MOL File: 1474110-21-8.mol

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N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide Property

Boiling point:: 622.6±65.0 °C(Predicted)
Density: 1.180±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤15mg/ml in ethanol;5mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 14.10±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20974
Product name: GSK2981278
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20974
Product name: GSK2981278
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 20974
Product name: GSK2981278
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 20974
Product name: GSK2981278
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

ApexBio Technology

Product number: C3707
Product name: GSK2981278
Packaging: 25mg
Price: $705
Updated: 2021/12/16

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N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide Chemical Properties,Usage,Production

Biological Activity

gsk2981278 is a rorγ-selective inverse agonist.rar-related orphan receptor gamma (rorγ) is a protein that in humans is encoded by the rorc gene. the rorγ protein is a dna-binding transcription factor and is a member of the nr1 subfamily of nuclear receptors.

in vitro

previous study found that gsk2981278 had no significant effect on rorα-dependent activation, indicating its selectivity for rorγ. gsk2981278 also demonstrated 10-fold greater potency for il-17a inhibition than its analogs of gsk3038548 and gsk3038549. in addition, authors examined the effect of gsk2981278 on endogenous il17a expression in jurkat cells. results showed that gsk2981278 could repress the activation of il17a by rorγt in a dose-responsive manner [1].

in vivo

in previous study, the imiquimod (imq) mouse model was employed to demonstrate efficacy of gsk2981278 in a psoriaform-like mouse model. results showed that the topical application of imq could induce and exacerbate psoriasis-like chronic skin inflammation in mice. next, mice were treated topically with gsk2981278 for three days, after which mice continued to receive compound for the duration of the study. it was found that gsk2981278 was undetectable in serum at harvest, suggesting that systemic exposure was minimal. in addition, mice exposed to gsk2981278 exhibited reduced skin redness and scaling, as well as decreased hyperplasia [1].

References

[1] smith sh et al. development of a topical treatment for psoriasis targeting rorγ: from bench to skin. plos one. 2016 feb 12;11(2):e0147979.
[2] https://clinicaltrials. gov/ct2/show/nct02548052 term=gsk2981278&rank=2

N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide Suppliers

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1474110-21-8, N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamideRelated Search:

GSK3008348 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate GSK2983559 cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate GSK3175047 GSK2982772 GSK2894631A GSK-2881078 GSK3145095 GSK3039294

ROR gamma GS2981278

CS-2157

N-(4-Ethyl-phenyl)-3-hydroxymethyl-N-isobutyl-4-(tetrahydro-pyran-4-ylmethoxy)-benzenesulfonamide

N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

ROR gama modulator 1

GSK2981278

GSK-2981278;GSK 2981278;ROR GAMA MODULATOR 1

Benzenesulfonamide, N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-

IL-22,ointment,RAR-related orphan receptor,psoriasis,topically,GSK2981278,GSK 2981278,inflammation,il17,inverse,binding,IL-17A,ROR,inhibit,RORγ-DNA,Inhibitor,GSK-2981278

N-(4-ethylphenyl)-3-(hydroxymethyl)-N-(2-methylpropyl)-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-benzenesulfonamide

1474110-21-8