5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
- Product Name
- 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
- CAS No.
- 7630-74-2
- Chemical Name
- 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
- Synonyms
- dehydronuciferin;ehydronuciferine;videoconferencing;Dehydronuciferine;dehydronuciferinene;Dehydronuciferine, 10 mM in DMSO;1,2-dimethoxy-6-methyl-5,6-dihydro-4H-dibenzo[de,g]quinoline;5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline;4H-Dibenzo[de,g]quinoline, 5,6-dihydro-1,2-dimethoxy-6-methyl-;5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline USP/EP/BP
- CBNumber
- CB43038422
- Molecular Formula
- C19H19NO2
- Formula Weight
- 293.36
- MOL File
- 7630-74-2.mol
5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline Property
- Boiling point:
- 493.0±45.0 °C(Predicted)
- Density
- 1.193±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.04±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C19H19NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,10-11H,8-9H2,1-3H3
- InChIKey
- JBGSWIBJAGBGOP-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C3C(C(OC)=C(OC)C=C3CC1)=C1C=CC=CC1=C2
N-Bromosuccinimide Price
- Product number
- FD165742
- Product name
- Dehydronuciferine
- Packaging
- 2mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD165742
- Product name
- Dehydronuciferine
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD165742
- Product name
- Dehydronuciferine
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD165742
- Product name
- Dehydronuciferine
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0032561
- Product name
- Dehydronuciferine
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline Chemical Properties,Usage,Production
Uses
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL[1].
Definition
ChEBI: Dehydronuciferine is an isoquinoline alkaloid.
Synthesis
The preparation process for total alkaloid extracts from lotus leaves generally comprises the following steps: (1) Extraction: The solvent employed may be water or any alcohol, ketone, or ester solvent; a mixed solvent composed of these solvents in specific proportions; or acidic or alkaline solvents formulated by combining these solvents with acids or alkalis. The preferred extraction method involves adding 30?C90% ethanol to lotus leaf material, followed by reflux extraction for 2?C3 cycles, each lasting 1?C2 hours, with a solvent volume of 15?C30 times the material weight (L/kg). (2) Filtration: Includes methods such as centrifugation, vacuum filtration, ultrafiltration, and pressure filtration, with or without the use of any one or a combination of the following clarifying agents: alcohol precipitants, gelatin, kaolin, various resins, polyethylene glycol, polyethylene triol, chitosan, and commercial natural clarifying agents such as 101 Juice Clarifier or ZTC+1 Natural Clarifier. (3) Concentration: Includes thin-film evaporation, rotary evaporation, and decoction concentration under atmospheric or reduced pressure conditions. (4) Drying: Includes vacuum drying, spray drying, and freeze drying. The composition of active alkaloid constituents from lotus leaves is extracted and prepared from the dried leaves of Nelumbonum nectariniflorum Gaertn., containing multiple alkaloid active components. These alkaloids primarily include lotus leaf alkaloid, N-demethyl lotus leaf alkaloid, O-demethyl lotus leaf alkaloid, saponin alkaloid, lotus alkaloid, lotus leaf alkaloid, N-demethylamaphylline, 2-hydroxy-1-methoxyapomorphine, amaphylline, N-methylisohengzhouwuyaoine, N-methylhengzhouwuyaoine, dehydrohepenine, dehydrolotusine, and other derivatives based on their parent nucleus.
References
[1] Yang, et al. Synthesis and structure-activity relationship of nuciferine derivatives as potential acetylcholinesterase inhibitors. Medicinal Chemistry Research June 2014, Volume 23, Issue 6, pp 3178–3186
5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline Suppliers
- Tel
- 18224028459 18224028459
- Fax
- QQ137193152
- yirui307@163.com
- Country
- China
- ProdList
- 1048
- Advantage
- 58
- Tel
- +86-028-82633397 18982077548
- Fax
- +86-28-82633165
- cwb1@biopurify.cn
- Country
- China
- ProdList
- 2376
- Advantage
- 60
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3988
- Advantage
- 66
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 021-61847300 13341622919
- Fax
- 021-61847300
- shcss01@163.com
- Country
- China
- ProdList
- 4808
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 10409
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
View Lastest Price from 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline manufacturers
- Product
- 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline 7630-74-2
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09