N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

Product Name: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine
CAS No.: 81256-89-5
Chemical Name: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine
Synonyms: 5'-DMT-3'-TBDMS-ibu-rG;5'-O-DMT-3'-O-TBDMS-ibu-rG;5'-O-DMT-3'-O-TBDMS-ibu-rG;5'-O-DMT-3'-O-TBDMS-N2-IBU-RG;3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine;5'-O-DMT-3'-O-(tertbutyldimethylsilyl)-N-isobutyryl-Guanosine;N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine;5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N2-isobutyryl-Guanosine;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-Guanosine;Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-
CBNumber: CB43052895
Molecular Formula: C41H51N5O8Si
Formula Weight: 769.96
MOL File: 81256-89-5.mol

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N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine Property

Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 4°C, away from moisture and light
solubility: DMSO : 100 mg/mL (129.88 mM; Need ultrasonic)
form: Solid
pka: 9.16±0.20(Predicted)
color: White to off-white
InChIKey: XAIQBZNFPUNWMQ-HVXBIEPNNA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](O)[C@@H]1O[Si](C(C)(C)C)(C)C |&1:25,27,44,46,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: NB33744
Product name: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB33744
Product name: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
Packaging: 500mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 9950EM
Product name: 5'-DMT-3'-TBDMS-ibu-rG
Packaging: 500mg
Price: $299
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB33744
Product name: 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine
Packaging: 1g
Price: $350
Updated: 2021/12/16

AK Scientific

Product number: 9950EM
Product name: 5'-DMT-3'-TBDMS-ibu-rG
Packaging: 1g
Price: $522
Updated: 2021/12/16

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N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine Chemical Properties,Usage,Production

Uses

5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside. 5'-DMT-3'-TBDMS-ibu-rG can be used in deoxyribonucleic acid synthesis.

Synthesis

18162-48-6

81246-83-5

81256-89-5

Synthesis of 3'-DMTBS-5'-O-(4,4') tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide from tert-butyldimethylchlorosilane and N-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(1-hydroxy-2,2-bis(4-methoxyphenyl)-2-phenylethyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide. -dimethoxytrityl)-N2-isobutyryl acylcytidine in the following general steps: to a solution of compound HLH (23.9 g, 36.450 mmol, 1.00 eq.) in N,N-dimethylformamide (120 mL) was added tert-butyldimethylchlorosilane (8.24 g, 54.675 mmol, 1.50 eq.) and 1H-imidazole ( 6.204 g, 91.124 mmol, 2.50 equiv). The reaction mixture was stirred at 25 °C overnight. After completion of the reaction, the reaction was quenched with methanol (5 mL) and the mixture was concentrated to give the residue. The residue was purified by preparative HPLC (mobile phase: water (containing 0.225% formic acid)-acetonitrile gradient elution) to afford compound LII (6.7 g, 24% yield) as a yellow solid.LC-MS analysis showed ESI-MS m/z 770.3 [M+H]+.

References

[1] Ezequiel Wexselblatt, et al. ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria. Bioorg Med Chem. 2010 Jun 15;18(12):4485-97. DOI:10.1016/j.bmc.2010.04.064

N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine Suppliers

China 32 United Kingdom 1 United States 4 Global 37

Carbosynth

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View Lastest Price from N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 5'-DMT-3'-TBDMS-ibu-rG 81256-89-5
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-03

81256-89-5, N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosineRelated Search:

5'-O-DMTr-N2-isobutyrylguanosine N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 5'-DMT-RIBO ADENOSINE (N-BZ) 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

5'-DMT-3'-TBDMS-ibu-rG

3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine

N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine

5'-O-DMT-3'-O-TBDMS-N2-IBU-RG

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-

5'-O-DMT-3'-O-TBDMS-ibu-rG

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-Guanosine

5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N2-isobutyryl-Guanosine

5'-O-DMT-3'-O-(tertbutyldimethylsilyl)-N-isobutyryl-Guanosine

5'-O-DMT-3'-O-TBDMS-ibu-rG

81256-89-5