ChemicalBook > CAS DataBase List > Ixazomib citrate

Ixazomib citrate

Product Name: Ixazomib citrate
CAS No.: 1239908-20-3
Chemical Name: Ixazomib citrate
Synonyms: (R)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid;lxazomib;MLN9708（b）;Ixazomib citrat;Esazomib citrate;Lxazomib Citrate;Ixazomib-prodrug;Ixazomib Citrate;Ixazomibe citrate;S-Ixazomib citrate
CBNumber: CB43067499
Molecular Formula: C20H23BCl2N2O9
Formula Weight: 517.12
MOL File: 1239908-20-3.mol

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Ixazomib citrate Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);193.38(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);193.38(Max Conc. mM)
form: Solid
pka: 3.59±0.10(Predicted)
color: White to off-white
InChIKey: MBOMYENWWXQSNW-AWEZNQCLSA-N
SMILES: O1C(=O)C(CC(O)=O)(CC(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: AG-CR1-3671-M001
Product name: Ixazomibcitrate[MLN9708]
Purity: ≥95%(1H-NMR)
Packaging: 1mg
Price: $35
Updated: 2021/12/16

ChemScene

Product number: CS-1720
Product name: Ixazomibcitrate
Purity: 99.80%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-1720
Product name: Ixazomibcitrate
Purity: 99.80%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CR1-3671-M005
Product name: Ixazomibcitrate[MLN9708]
Purity: ≥95%(1H-NMR)
Packaging: 5mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-1720
Product name: Ixazomibcitrate
Purity: 99.80%
Packaging: 50mg
Price: $150
Updated: 2021/12/16

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Ixazomib citrate Chemical Properties,Usage,Production

Uses

Ixazomib Citrate is a reversible boronic acid proteasome inhibitor.

Definition

ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diy }diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.

Health effects

Ixazomib citrate is an N-capped dipeptidyl leucine boronic acid like bortezomib, and it is able to inhibit the chymotrypsin-like proteolytic site of the 20S proteasome.

Side effects

Common side effects of Ixazomib citrate include diarrhea, constipation and low platelet count. Like the older bortezomib (which can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative.

in vivo

Ixazomib citrate (MLN9708; 11 mg/kg) significantly inhibits MM tumor growth and prolongs survival in the human plasmacytoma MM.1S xenograft mouse model. The blood chemistry profiles of Ixazomib-treated mice show normal levels of creatinine, hemoglobin, and bilirubin. Ixazomib dramatically increases the number of cleaved-caspase-3 positive cells of the xenograft model^[2].

Ixazomib citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ixazomib citrate manufacturers

Cangzhou Kangrui Pharma Tech Co. Ltd.,

Product: Ixazomib Citrate 1239908-20-3
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10kgs
Release date: 2024-11-05

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Ixazomib Citrate 1239908-20-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-13

Career Henan Chemical Co

Product: Ixazomib citrate (USAN) 1239908-20-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

1239908-20-3, Ixazomib citrateRelated Search:

MLN9708 Ixazomib Impurity 1 Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]- (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Repaglinide Bendamustine Ibrutinib Bortezomib Carfilzomib

Ixazomib citrate (USAN)

2-[(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diacetic acid

2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid

IXAZOMIB CITRATE;MLN 9708;MLN-9708

(R)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid

Ixazomib citrate(MLN9708)

IXAZOMIB; MLN-9708;MLN9708;MLN 9708

2-[4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolan-4-yl]acetic acid

Esazomib citrate

1,3,2-Dioxaborolane-4,4-diacetic acid, 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-

Ixazomib Impurity 19

(R)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid compound with 2-hydroxypropane-1,2,3-tricarboxylic acid (1:1)

MLN 9708 / Ixazomib citrate / 1,3,2-Dioxaborolane-4,4-diacetic acid, 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-

Lxazomib Citrate

Ixazomib citrat

MLN9708（b）

Ixazomib citrate (USAN)（For R & D only）

Ixazomib-prodrug

lxazomib

S-Ixazomib citrate

Ixazomib Impurity 23 (Ixazomib Citrate)

Ixazomib Impurity N

Ixazomib citrate, 10 mM in DMSO

Ixazomibe citrate

Escrazomil citrate

Ixazomib Citrate

(R)-2,2'-(2-(1-(2-(2,5-Dichlorobenzcarboxcarboxcarboxamido)-acetcarboxcarboxcarboxamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid

1239908-20-3

API