4BP-TQS Property

Melting point:

>202°C (dec.)

Boiling point:

566.2±60.0 °C(Predicted)

Density 

1.505±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

powder

pka

10.21±0.40(Predicted)

color 

white to beige

Hazard and Precautionary Statements (GHS)

4BP-TQS Chemical Properties,Usage,Production

Uses

4BP-TQS is an agonist of human α7 nicotinic acetylcholine receptor (a7-nAChR), activates the channel via binding to an allosteric transmembrane site. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.

Biochem/physiol Actions

4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.