GRL0617

Product Name: GRL0617
CAS No.: 1093070-16-6
Chemical Name: GRL0617
Synonyms: RL 0617;GRL0617 ，S6845;GRL-0617 (GRL0617;GRL0617, 10 mM in DMSO;5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide;(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide;Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV
CBNumber: CB43085996
Molecular Formula: C20H20N2O
Formula Weight: 304.39
MOL File: 1093070-16-6.mol

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GRL0617 Property

Boiling point:: 514.9±50.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
form: solid
pka: 14.26±0.46(Predicted)
color: Beige
optical activity: [α]/D -72.0 to -82.0°, c =0.5 in chloroform-d
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
InChIKey: UVERBUNNCOKGNZ-CQSZACIVSA-N
SMILES: C(N[C@@H](C1=C2C(C=CC=C2)=CC=C1)C)(=O)C1=CC(N)=CC=C1C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2961
Product name: GRL-0617
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $118
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2961
Product name: GRL-0617
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $473
Updated: 2026/03/19

ChemScene

Product number: CS-0063568
Product name: GRL0617
Purity: 99.78%
Packaging: 50mg
Price: $2000
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0000212
Product name: 5-AMINO-2-METHYL-N-(1R-NAPHTHALEN-1-YL-ETHYL)-BENZAMIDE
Purity: 95.00%
Packaging: 100MG
Price: $2252.25
Updated: 2021/12/16

ChemScene

Product number: CS-0063568
Product name: GRL0617
Purity: 99.78%
Packaging: 100mg
Price: $3000
Updated: 2021/12/16

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GRL0617 Chemical Properties,Usage,Production

Description

GRL-0617 (1093070-16-6) is a potent (IC50= 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50= 15 μM).Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2

Chemical Properties

Appearance: Solid, beige. Boiling point: 514.9 ± 50.0°C (predicted). Density: 1.168 ± 0.06 g/cm (predicted). Solubility: Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL). Optical rotation: [α]/D -72.0 to -82.0°, c = 0.5 in chloroform-d.

Uses

GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome[1].

Definition

ChEBI: GRL-0617 is a benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). It has a role as an anticoronaviral agent and a protease inhibitor. It is a member of naphthalenes, a substituted aniline, a member of benzamides and a secondary carboxamide.

storage

Store at -20°C

References

[1] GAO X, CUI S. Crystal structure of the SARS-CoV-2 PLpro with GRL0617[C]. 2020: 0. DOI:10.2210/PDB7CMD/PDB.
[2] LUKAS KERTI Vladimir F. Design of inhibitors of SARS-CoV-2 papain-like protease deriving from GRL0617: Structure–activity relationships[J]. Bioorganic & Medicinal Chemistry, 2024, 113: Article 117909. DOI:10.1016/j.bmc.2024.117909.
[3] PRIYASHI RAO. Identifying structural–functional analogue of GRL0617, the only well-established inhibitor for papain-like protease (PLpro) of SARS-CoV2 from the pool of fungal metabolites using docking and molecular dynamics simulation[J]. Molecular Diversity, 2021, 26 1: 309-329. DOI:10.1007/s11030-021-10220-8.
[4] KIIRA RATIA. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 16119-16124. DOI:10.1073/pnas.0805240105.

GRL0617 Preparation Products And Raw materials

Raw materials

Preparation Products

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GRL0617 Suppliers

China 60 United States 6 Global 66

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 3000
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9675
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Zhuzhou focus pharmaceutical technology co., LTD

Tel: +86-13776644403
Email: robert@focuspharma.cc
Country: China
ProdList: 2498
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1093070-16-6, GRL0617Related Search:

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5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide

GRL-0617 (GRL0617

Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-

GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV

(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide

5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide

RL 0617

GRL0617, 10 mM in DMSO

GRL0617 ，S6845

1093070-16-6