5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
- Product Name
- 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
- CAS No.
- 1093070-16-6
- Chemical Name
- 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
- Synonyms
- RL 0617;GRL-0617 (GRL0617;5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide;(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide;Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV
- CBNumber
- CB43085996
- Molecular Formula
- C20H20N2O
- Formula Weight
- 304.39
- MOL File
- 1093070-16-6.mol
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Property
- Boiling point:
- 514.9±50.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL)
- form
- solid
- pka
- 14.26±0.46(Predicted)
- color
- Beige
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 4575DF
- Product name
- 5-Amino-2-methyl-N-[2-(naphthalen-1-yl)ethyl]benzamide
- Packaging
- 10mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CS-0063568
- Product name
- GRL0617
- Purity
- 99.78%
- Packaging
- 10mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CCH0000212
- Product name
- 5-AMINO-2-METHYL-N-(1R-NAPHTHALEN-1-YL-ETHYL)-BENZAMIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $866.25
- Updated
- 2021/12/16
- Product number
- CS-0063568
- Product name
- GRL0617
- Purity
- 99.78%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0063568
- Product name
- GRL0617
- Purity
- 99.78%
- Packaging
- 50mg
- Price
- $2000
- Updated
- 2021/12/16
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Chemical Properties,Usage,Production
Description
GRL-0617 (1093070-16-6) is a potent (IC50?= 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50?= 15 μM).??Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2
Definition
ChEBI: GRL-0617 is a benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). It has a role as an anticoronaviral agent and a protease inhibitor. It is a member of naphthalenes, a substituted aniline, a member of benzamides and a secondary carboxamide.
storage
Store at -20°C
References
1)????Ratia?et al. (2008),?A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication;?Proc. Natl. Acad. Sci. USA,?105?16119
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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