Acamprosate calcium
- Product Name
- Acamprosate calcium
- CAS No.
- 77337-73-6
- Chemical Name
- Acamprosate calcium
- Synonyms
- Aotal;CaAOTA;AlcoMed;Sobriol;CaMpral EC;trans-N-Boc-1;Calcium acanate;2R)-trans-N-Boc-1;ALAMPROSATECALCIUM;ACAMPROSATE CALCIUM
- CBNumber
- CB4310705
- Molecular Formula
- C10H20CaN2O8S2
- Formula Weight
- 400.48
- MOL File
- 77337-73-6.mol
Acamprosate calcium Property
- Melting point:
- >300°C
- storage temp.
- 2-8°C
- solubility
- H2O: >5mg/mL
- form
- powder
- color
- White to Off-White
- Water Solubility
- Soluble in water (100mM)
- Merck
- 14,17
- CAS DataBase Reference
- 77337-73-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36
- WGK Germany
- 3
- RTECS
- TZ6357000
- HS Code
- 29241990
- Toxicity
- LD50 i.p. in male mice: 1.87 g/kg (Durlach, 1982)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A6981
- Product name
- Acamprosate calcium
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- BP1172
- Product name
- Acamprosate calcium
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 1000554
- Product name
- Acamprosate calcium
- Purity
- United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2)
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- A2359
- Product name
- Acamprosate Calcium
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 23899
- Product name
- Acamprosate (calcium salt)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $44
- Updated
- 2024/03/01
Acamprosate calcium Chemical Properties,Usage,Production
Description
Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
Chemical Properties
Acamprosate calcium is White Crystalline Solid
Originator
Campral,Merck
Uses
Of interest for the treatment of alcoholism. Store at -20°C
Uses
glucocortcoid, antiinflammatory
Uses
Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
Uses
Of interest for the treatment of alcoholism and other neurochemical disorders.
Definition
ChEBI: Acamprosate calcium is an organic calcium salt. It contains an acamprosate(1-).
Manufacturing Process
In a 4 liter flask provided with stirring means, a bromine funnel and a
thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic
acid (homotaurine) are added.
After complete dissolution, at a temperature of between 25°-40°C, acetic
anhydride are added so as not to exceed a temperature of between 30°-40°C.
The mixture is then maintained at this temperature by heating for at least 1
h.
The solution is then concentrated in vacuum, the residue is redissolved in 2.5
L of distilled water and the mixture is concentrated again. The residue is then
dissolved in 1.6 L of distilled water, filtered, then concentrated almost
completely. Drying is terminated in an oven in vacuum. A colorless crystalline
powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate)
is obtained.
The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3-
acetylaminopropanesulfonate of sodium with hydrochloric acid.
In practice it is usually used as calcium salt.
brand name
Campral (Forest).
Therapeutic Function
Psychotropic
Biological Activity
GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Biochem/physiol Actions
Acamprosate calcium is a GABA γ-aminobutyric acid agonist.
Clinical Use
Maintenance of abstinence in alcohol dependence
Metabolism
Acamprosate is excreted in the urine and is not metabolised significantly.
storage
Room temperature (desiccate)
References
1. wilde m i, wagstaff a j. acamprosate. drugs, 1997, 53(6): 1038-1053.
Acamprosate calcium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acamprosate calcium manufacturers
- Product
- Acamprosate calcium 77337-73-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30