3-Amino-1-propanesulfonic acid
- Product Name
- 3-Amino-1-propanesulfonic acid
- CAS No.
- 3687-18-1
- Chemical Name
- 3-Amino-1-propanesulfonic acid
- Synonyms
- HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
- CBNumber
- CB2741107
- Molecular Formula
- C3H9NO3S
- Formula Weight
- 139.17
- MOL File
- 3687-18-1.mol
3-Amino-1-propanesulfonic acid Property
- Melting point:
- 293 °C (dec.)(lit.)
- Density
- 1.202 (estimate)
- refractive index
- 1.5130 (estimate)
- storage temp.
- 2-8°C
- solubility
- Water (Slightly)
- pka
- 1.06±0.50(Predicted)
- form
- Crystalline Powder
- color
- White to slightly blue
- InChI
- InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
- InChIKey
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N
- SMILES
- C(S(O)(=O)=O)CCN
- LogP
- -4.555
- CAS DataBase Reference
- 3687-18-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0000116
- Product name
- Acamprosate impurity A
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 110 mg
- Price
- $153
- Updated
- 2025/07/31
- Product number
- PHR2822
- Product name
- Acamprosate Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50MG
- Price
- $494.95
- Updated
- 2025/07/31
- Product number
- A76109
- Product name
- 3-Amino-1-propanesulfonic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $46.64
- Updated
- 2025/07/31
- Product number
- 1000565
- Product name
- Acamprosate Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $1130
- Updated
- 2025/07/31
- Product number
- A2602
- Product name
- 3-Amino-1-propanesulfonic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $127
- Updated
- 2025/07/31
3-Amino-1-propanesulfonic acid Chemical Properties,Usage,Production
Description
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemical Properties
White Powder
Uses
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Definition
ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.
Biological Activity
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ISMAEL SANTA-MARIA. Tramiprosate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau.[J]. Molecular Neurodegeneration, 2007: 17. DOI: 10.1186/1750-1326-2-17
[3] A. GIOTTI. Homotaurine: a GABAB antagonist in guinea-pig ileum[J]. British Journal of Pharmacology, 1983, 79 4: 855-862. DOI: 10.1111/j.1476-5381.1983.tb10529.x
3-Amino-1-propanesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-1-propanesulfonic acid Suppliers
- Tel
- 0571-88938669 18667135863
- wps@highfine.com
- Country
- China
- ProdList
- 165
- Advantage
- 60
- Tel
- 021-50158063
- Fax
- 021-6153 1846
- sales@elivpharma.com
- Country
- China
- ProdList
- 477
- Advantage
- 58
- Tel
- 13771737464
- sales@dolanchem.com
- Country
- China
- ProdList
- 2172
- Advantage
- 58
- Tel
- 021-52277372 13564545227
- sales@eyougene.com
- Country
- China
- ProdList
- 164
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
View Lastest Price from 3-Amino-1-propanesulfonic acid manufacturers
- Product
- 3-Amino-1-propanesulfonic acid 3687-18-1
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-12-04
- Product
- 3-Amino-1-propanesulfonic acid 3687-18-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- 3-Amino-1-propanesulfonic acid 3687-18-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-13