3-Amino-1-propanesulfonic acid

Product Name: 3-Amino-1-propanesulfonic acid
CAS No.: 3687-18-1
Chemical Name: 3-Amino-1-propanesulfonic acid
Synonyms: HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
CBNumber: CB2741107
Molecular Formula: C3H9NO3S
Formula Weight: 139.17
MOL File: 3687-18-1.mol

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3-Amino-1-propanesulfonic acid Property

Melting point:: 293 °C (dec.)(lit.)
Density: 1.202 (estimate)
refractive index: 1.5130 (estimate)
storage temp.: 2-8°C
solubility: Water (Slightly)
pka: 1.06±0.50(Predicted)
form: Crystalline Powder
color: White to slightly blue
LogP: -4.555
CAS DataBase Reference: 3687-18-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 1
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A76109
Product name: 3-Amino-1-propanesulfonic acid
Purity: 97%
Packaging: 1g
Price: $47.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2822
Product name: Acamprosate Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1000565
Product name: Acamprosate Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $1140
Updated: 2024/03/01

TCI Chemical

Product number: A2602
Product name: 3-Amino-1-propanesulfonic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $127
Updated: 2024/03/01

TCI Chemical

Product number: A2602
Product name: 3-Amino-1-propanesulfonic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $317
Updated: 2024/03/01

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3-Amino-1-propanesulfonic acid Chemical Properties,Usage,Production

Description

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

Chemical Properties

White Powder

Uses

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

Definition

ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .

3-Amino-1-propanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-1-propanesulfonic acid Suppliers

Americas 1 Belgium 3 Brazil 1 Canada 4 China 247 Czech Republic 1 Europe 3 Germany 6 India 15 Japan 2 Slovakia 1 Switzerland 2 United Kingdom 11 United States 49 Global 346

Shanghai eliv pharmaceutical Co.,Ltd.

Tel: 021-50158063
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INTATRADE GmbH

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
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View Lastest Price from 3-Amino-1-propanesulfonic acid manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Tramiprosate 3687-18-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.91%
Supply Ability: 200000
Release date: 2024-04-17

Henan Fengda Chemical Co., Ltd

Product: 3-Amino-1-propanesulfonic acid 3687-18-1
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

airuikechemical co., ltd.

Product: 3-amino-1-propanesulfonic acid 3687-18-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

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aminopropanesulfonicacid,3-aminopropanesulfonicacid

HOMOTAURINE

3-AMINO-1-PROPANESULFONIC ACID

3-AMINOPROPANESULFONIC ACID

3 APS

3-aminopropane-1-sulphonic acid

TRAMIPROSATE

3-AMINOPROPANE-1-SULFONIC ACID

3-Aminopropiosulfonic Acid

3-Sulfopropylamine

Alzhemed

NC 758

NSC 77071

1-Propanesulfonic acid, 3-amino-

3-AMino-1-propanesulfonic acid (HoMotaurine)

AcaMprosate Related CoMpound A

3-AMino-1-propanesulfonic acid 97%

Homotaurin

3-Aminopropan-1-sulfonsure

3-Amino-1-propanesulfonic acid,95%

3-Amino-1-propanesulfonic acid,3APS, Homotaurine, Tramiprosate

HoMotaurine (3-AMinopropanesulfonic Acid)

3-AMino-1-propanesulfonic acid, 95% 1GR

TRAMIP

3-Aminopropanesulfonate

Acamprosate Impurity 1（Acamprosate USP RC A）

-Amino-1-propanesulfonic acid

Acamprosate EP Impurity A (Homotaurine)

3-Amino-1-propanesulfonic Acid &gt

Acamprosate impurity A CRS

3-Aminopropane-1-sulfonic Acid (Hom

3-Amino-1-propanesulfonic acid ISO 9001：2015 REACH

Acamprosate calcium EP Impurity A

-Amino-1-propanesulfonic acid

Acamprosate Related Compound A (3-aminopropane-1-sulfonic acid) (1000565)

3-Amino-1-propanesulfonic

Acamprosate USP Related Compound A

Acamprosate Calcium Impurity A

3687-18-1

H2NCH23SO3H

SULFONIC ACID

Building Blocks

Sulfonic/Sulfinic Acids

Sulfur Compounds

Organic Building Blocks

API

Inhibitors

Metal Isotopes

Sulfur & Selenium Compounds

Organic Building Blocks

Sulfonic/Sulfinic Acids

Sulfur Compounds

Pharmaceutical Raw Materials