Description application Reference
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MOPS

Description application Reference
Product Name
MOPS
CAS No.
1132-61-2
Chemical Name
MOPS
Synonyms
MOPS;3-(N-MORPHOLINO)PROPANESULFONIC ACID;MOPS FREE ACID;MORPHOLINOPROPANE SULFONIC ACID;3-Morpholinopropanesulfoinc Acid;4-morpholinopropanesulphonic acid;3-Morpholinopropane-1-sulfonic acid;WAS 15;MOPS,≥98%;MOPS1132-61-2
CBNumber
CB0221586
Molecular Formula
C7H15NO4S
Formula Weight
209.26
MOL File
1132-61-2.mol
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MOPS Property

Melting point:
277-282 °C
Density 
1.3168 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.6370 (estimate)
Flash point:
116 °C
storage temp. 
room temp
solubility 
H2O: 1 M at 20 °C, clear
form 
Powder/Solid
color 
White
PH
2.5-4.0 (25℃, 1M in H2O)
pka
7.2(at 25℃)
PH Range
6.5 - 7.9
Odor
Odorless
Water Solubility 
1000 g/L (20 ºC)
λmax
λ: 260 nm Amax: 0.020
λ: 280 nm Amax: 0.015
Merck 
14,6265
BRN 
1106776
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents.
InChIKey
DVLFYONBTKHTER-UHFFFAOYSA-N
LogP
-2.94 at 20℃
CAS DataBase Reference
1132-61-2(CAS DataBase Reference)
EPA Substance Registry System
4-Morpholinepropanesulfonic acid (1132-61-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
QE9104530
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHG0007
Product name
MOPS
Packaging
1KIT
Price
$1191
Updated
2024/03/01
Sigma-Aldrich
Product number
M3183
Product name
MOPS
Purity
BioPerformance Certified, suitable for cell culture, ≥99.5% (titration)
Packaging
25KG
Price
$9130
Updated
2024/03/01
Sigma-Aldrich
Product number
M1254
Product name
MOPS
Purity
≥99.5% (titration)
Packaging
25KG
Price
$7580
Updated
2024/03/01
Sigma-Aldrich
Product number
69947
Product name
MOPS
Purity
BioUltra, for molecular biology, ≥99.5% (T)
Packaging
25g
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
69947
Product name
MOPS
Purity
BioUltra, for molecular biology, ≥99.5% (T)
Packaging
100g
Price
$414
Updated
2024/03/01
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MOPS Chemical Properties,Usage,Production

Description

MOPS (3-morpholinopropanesulfonic acid) is a buffer introduced by Good et al. in the 1960s. It is a structural analog to MES. Its chemical structure contains a morpholine ring. HEPES is a similar pH buffering compound that contains a piperazine ring. With a pKa of 7.20, MOPS is an excellent buffer for many biological systems at near-neutral pH.It is used as a synthetic buffering agent below pH 7.5.

application

MOPS is frequently used as a buffering agent in biology and biochemistry. It has been tested and recommended for polyacrylamide gel electrophoresis. Usage above 20 mM in mammalian cell culture work is not recommended. MOPS buffer solutions become discolored (yellow) over time, but reportedly slight discoloration does not significantly affect the buffering characteristics.

Reference

P. H. Quail, D. Marme, E. Schäfer, Particle-bound phytochrome from maize and pumpkin, Nature New Biology, 1973, vol. 245, pp. 189-191

Chemical Properties

White/clear crystalline powder

Uses

MOPS acts as a multi-purpose buffering agent used in various biological research.

Uses

Due to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production,  a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.

Definition

ChEBI: 3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 ℃. It is a member of morpholines, a MOPS and an organosulfonic acid. It is a conjugate acid of a 3-(N-morpholino)propanesulfonate. It is a tautomer of a 3-(N-morpholiniumyl)propanesulfonate.

General Description

3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.

Flammability and Explosibility

Not classified

Synthesis

Morpholine and 1,3-Propanesultone are added to absolute ethanol for reaction. The crude product synthesized is purified to obtain 3-Morpholinopropanesulfonic acid.

MOPS Preparation Products And Raw materials

Raw materials

Preparation Products

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MOPS Suppliers

Hubei New Desheng Materials Technology Co., Ltd.
Tel
18971041571
Fax
0711-3704589
Email
vickyzhao@whdschem.com
Country
China
ProdList
57
Advantage
58
Nanjing Search Biotech Co., Ltd
Tel
+86-025-81682922 +86-13515111588
Fax
025-85860962
Email
sales@searchbio.com.cn
Country
China
ProdList
135
Advantage
68
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4531
Advantage
62
Hunan Waybel Advanced Materials Co.,Ltd
Tel
0745-2866851 19366977416
Email
3002708854@qq.com
Country
China
ProdList
436
Advantage
60
Hubei ZhengXingyuan Chemical Co., Ltd.
Tel
027-87879183,027-87633098 15207106154
Fax
027-87877281
Email
2905723734@qq.com
Country
China
ProdList
274
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 13451648594
Fax
0512-87182056
Email
sales@yacoo.com.cn
Country
China
ProdList
4987
Advantage
58
Hunan Wokai Biotechnology Co., Ltd.
Tel
0744-2221508 13126795102
Fax
0744-6652010
Email
2577930172@qq.com
Country
China
ProdList
319
Advantage
58
Hubei deante Chemical Technology Co., Ltd
Tel
15927262683
Email
3244356795@qq.com
Country
China
ProdList
296
Advantage
58
Hunan Hengfei bio-pharmaceutical Co. , Ltd.
Tel
0746-6222194 13874779848
Fax
0746-6222194
Email
57182844@qq.com
Country
China
ProdList
86
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
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View Lastest Price from MOPS manufacturers

Suzhou Genemill Biotechnology Co.,Ltd
Product
MOPS-3-Morpholinopropanesulfonic Acid 1132-61-2
Price
US $40.00/kg
Min. Order
1kg
Purity
0.995
Supply Ability
100tons
Release date
2023-10-16
Suzhou Genemill Biotechnology Co.,Ltd
Product
MOPS 1132-61-2
Price
US $40.00/kg
Min. Order
1kg
Purity
0.995
Supply Ability
100tons
Release date
2023-09-13
Hebei Yanxi Chemical Co., Ltd.
Product
3-Morpholinopropanesulfonic acid 1132-61-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
6000kg
Release date
2023-09-04

1132-61-2, MOPSRelated Search:


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