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3-Amino-1-propanesulfonic acid

Product Name
3-Amino-1-propanesulfonic acid
CAS No.
3687-18-1
Chemical Name
3-Amino-1-propanesulfonic acid
Synonyms
HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
CBNumber
CB2741107
Molecular Formula
C3H9NO3S
Formula Weight
139.17
MOL File
3687-18-1.mol
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3-Amino-1-propanesulfonic acid Property

Melting point:
293 °C (dec.)(lit.)
Density 
1.202 (estimate)
refractive index 
1.5130 (estimate)
storage temp. 
2-8°C
solubility 
Water (Slightly)
pka
1.06±0.50(Predicted)
form 
Crystalline Powder
color 
White to slightly blue
LogP
-4.555
CAS DataBase Reference
3687-18-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A76109
Product name
3-Amino-1-propanesulfonic acid
Purity
97%
Packaging
1g
Price
$47.6
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2822
Product name
Acamprosate Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
1000565
Product name
Acamprosate Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1140
Updated
2024/03/01
TCI Chemical
Product number
A2602
Product name
3-Amino-1-propanesulfonic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
A2602
Product name
3-Amino-1-propanesulfonic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$317
Updated
2024/03/01
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3-Amino-1-propanesulfonic acid Chemical Properties,Usage,Production

Description

Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.

Chemical Properties

White Powder

Uses

3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.

Definition

ChEBI: 3-Aminopropanesulfonate is an organosulfonic acid.

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .

3-Amino-1-propanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-1-propanesulfonic acid Suppliers

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View Lastest Price from 3-Amino-1-propanesulfonic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
3-Amino-1-propanesulfonic acid 3687-18-1
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-12-04
Hebei Weibang Biotechnology Co., Ltd
Product
3-Amino-1-propanesulfonic acid 3687-18-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
airuikechemical co., ltd.
Product
3-amino-1-propanesulfonic acid 3687-18-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

3687-18-1, 3-Amino-1-propanesulfonic acidRelated Search:

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  • aminopropanesulfonicacid,3-aminopropanesulfonicacid
  • HOMOTAURINE
  • 3-AMINO-1-PROPANESULFONIC ACID
  • 3-AMINOPROPANESULFONIC ACID
  • 3 APS
  • 3-aminopropane-1-sulphonic acid
  • TRAMIPROSATE
  • 3-AMINOPROPANE-1-SULFONIC ACID
  • 3-Aminopropiosulfonic Acid
  • 3-Sulfopropylamine
  • Alzhemed
  • NC 758
  • NSC 77071
  • 1-Propanesulfonic acid, 3-amino-
  • 3-AMino-1-propanesulfonic acid (HoMotaurine)
  • AcaMprosate Related CoMpound A
  • 3-AMino-1-propanesulfonic acid 97%
  • Homotaurin
  • 3-Aminopropan-1-sulfonsure
  • 3-Amino-1-propanesulfonic acid,95%
  • 3-Amino-1-propanesulfonic acid,3APS, Homotaurine, Tramiprosate
  • HoMotaurine (3-AMinopropanesulfonic Acid)
  • 3-AMino-1-propanesulfonic acid, 95% 1GR
  • TRAMIP
  • 3-Aminopropanesulfonate
  • Acamprosate Impurity 1（Acamprosate USP RC A）
  • -Amino-1-propanesulfonic acid
  • Acamprosate EP Impurity A (Homotaurine)
  • 3-Amino-1-propanesulfonic Acid &gt
  • Acamprosate impurity A CRS
  • 3-Aminopropane-1-sulfonic Acid (Hom
  • 3-Amino-1-propanesulfonic acid ISO 9001：2015 REACH
  • Acamprosate calcium EP Impurity A
  • -Amino-1-propanesulfonic acid
  • Acamprosate Related Compound A (3-aminopropane-1-sulfonic acid) (1000565)
  • 3-Amino-1-propanesulfonic
  • Acamprosate USP Related Compound A
  • Acamprosate Calcium Impurity A
  • 3687-18-1
  • H2NCH23SO3H
  • SULFONIC ACID
  • Building Blocks
  • Sulfonic/Sulfinic Acids
  • Sulfur Compounds
  • Organic Building Blocks
  • API
  • Inhibitors
  • Metal Isotopes
  • Sulfur & Selenium Compounds
  • Organic Building Blocks
  • Sulfonic/Sulfinic Acids
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