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3-Amino-1-adamantanol

Product Name
3-Amino-1-adamantanol
CAS No.
702-82-9
Chemical Name
3-Amino-1-adamantanol
Synonyms
3-AMINO-1-ADAMANTANOL;3-AMINOADAMANTAN-1-OL;3-Amino-1-admantanol;4-aminoadamantan-1-ol;3-Amino-1-Adamantanamine;3-Hydroxy-1-aminoadamantane;1-AMINO-3-HYDROXYADAMANTANE;C1oH17NO;AKOS BB-9784;CHEMBRDG-BB 4003530
CBNumber
CB5777891
Molecular Formula
C10H17NO
Formula Weight
167.25
MOL File
702-82-9.mol
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3-Amino-1-adamantanol Property

Melting point:
265 °C (dec.)(lit.)
Boiling point:
266.8±23.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
Flash point:
230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
15.07±0.40(Predicted)
color 
White to yellow
Water Solubility 
Soluble in organic solvents,insoluble in water.
InChI
InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9/h7-8,12H,1-6,11H2
InChIKey
DWPIPTNBOVJYAD-UHFFFAOYSA-N
SMILES
C12(O)CC3CC(CC(N)(C3)C1)C2
CAS DataBase Reference
702-82-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
523690
Product name
3-Amino-1-adamantanol
Purity
96%
Packaging
1g
Price
$26
Updated
2024/03/01
Sigma-Aldrich
Product number
523690
Product name
3-Amino-1-adamantanol
Purity
96%
Packaging
5g
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
A2079
Product name
3-Amino-1-adamantanol Hydrate
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
A2079
Product name
3-Amino-1-adamantanol Hydrate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$40
Updated
2024/03/01
Alfa Aesar
Product number
H64137
Product name
3-Amino-1-adamantanol, 98+%
Packaging
5g
Price
$48.65
Updated
2024/03/01
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3-Amino-1-adamantanol Chemical Properties,Usage,Production

Description

3-Amino-1-adamantanol is an important adamantane drug intermediate mainly used in the synthesis of inhibitors with antihyperglycaemic properties for the preparation of Vildagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor used in the treatment of type 2 diabetes.

Chemical Properties

White solid

Uses

It is employed in the synthesis of inhibitors with antihyperglycemic properties. vil- dagliptin is synthesised from 3-Amino-1-adamantanol.

Uses

3-Amino-1-hydroxyadamantane can be employed in the synthesis of inhibitors with antihyperglycemic properties.

Uses

As reagent, 3-Amino-1-hydroxyadamantane can be used in the preparation of Vildagliptin.

Synthesis

A preparation method of 3-amino-1-adamantanol comprises the following steps: (1) adding amantadine or a salt thereof to sulfuric acid at 10-30 DEG C and adding a mixed acid dropwise to perform a nitration reaction to obtain a reaction liquid; (2) adding the reaction liquid to water and mixing the reaction liquid with water to obtain a mixed solution; (3) performing a hydroxylation reaction under the effect of alkaline to obtain the 3-amino-1-adamantanol. The preparation method employs the raw material, is easy to obtain, is simple in operations, is environmentally protective, is low in cost, and is high in yield, which is generally higher than 80%, maximally 90.1%.

3-Amino-1-adamantanol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-1-adamantanol Suppliers

Sichuan Zhongbang Pharma CO.,LTD
Tel
0830-0830-2585019 13679670161
Fax
0830-2589033
Email
sales2@zhongbangst.com
Country
China
ProdList
105
Advantage
69
TIANJIN MINXIANG BIOMEDICAL INC.
Tel
022-59596766 13313219033 18222332696
Fax
86-22-88718329
Email
jinpeng@mxpharm.com
Country
China
ProdList
98
Advantage
58
Wuxi Hailun Bio-Technology Co., Ltd.
Tel
0510-85629785 18051595327
Fax
0510-85625359
Email
sales@hlsw-bio.com
Country
China
ProdList
112
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Anhui Cheer-Our Medical technology Co.,Ltd
Tel
0551-63535381 13485700777
Email
gaylen@cheer-our.com
Country
China
ProdList
93
Advantage
58
Huzhou Chenxi Environmental Protection Technology Co., Ltd.
Tel
0572-0572-16762203950 16762203950
Email
3775386035@qq.com
Country
China
ProdList
70
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
ProdList
112
Advantage
61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
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View Lastest Price from 3-Amino-1-adamantanol manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
3-Amino-1-adamantanol 702-82-9
Price
US $99.00-66.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Amino-1-adamantanol 702-82-9
Price
US $40.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-17
Nanjing Fred Technology Co., Ltd
Product
3-Amino-1-hydroxyadamantane 702-82-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-02

702-82-9, 3-Amino-1-adamantanolRelated Search:


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